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Yoshida Lab
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A lab that uses bubble-based contrast-enhanced ultrasound to see inside the body.
AboutAbout the lab
Seeing inside the body with bubbles as contrast agents
The Yoshida Lab studies methods for seeing inside the body using bubbles that serve as ultrasound contrast agents.
It proposes a contrast-enhanced ultrasound method that uses nanobubbles, smaller than 1 micrometer in diameter, as the contrast agent, and works from confirming the basic phenomena through to verifying performance.
It aims to apply this to imaging of lymphatic vessels and lymph nodes and to methods for investigating how drugs move inside the body.
The lab also develops multifunctional contrast agents, in which a single formulation has multiple functions, and verifies the safety of ultrasound cavitation.
Key terms
- Contrast agent
- A drug put into the body so that the area to be examined shows up more clearly in images.
- Nanobubble
- An extremely fine bubble smaller than 1 micrometer in diameter.
- Cavitation
- A phenomenon in which a large negative pressure creates cavities (bubbles) in a liquid.
ResearchResearch themes
Centered on bubbles that serve as ultrasound contrast agents, the lab develops technologies that support treatment, aiming at applications such as visualizing lymphatic vessels inside the body. It also works on imaging that combines ultrasound with near-infrared fluorescence and on verifying the safety of ultrasound cavitation.
*Illustrative imageHighly sensitive contrast-enhanced ultrasound
The lab proposes a contrast-enhanced ultrasound method that uses nanobubbles as the contrast agent. Because contrast echoes are weak and hard to distinguish from tissue echoes, it focuses on the fact that the contrast agent moves when ultrasound is applied, and is developing a method that analyzes the phase information of the echo to form an image.
*Illustrative imageSeeing with ultrasound and fluorescence at the same time
Ultrasound imaging and near-infrared fluorescence imaging both use equipment that is easy to carry and offer good real-time performance, and they can make up for each other's weaknesses. The lab has developed fluorescent bubbles, in which a near-infrared fluorescent probe is built into an ultrasound contrast agent, and verifies their performance from basic characteristics through to clinical equipment.
*Illustrative imageSupporting treatment with giant vesicle aggregates
In surgery for malignant tumors, it is sometimes necessary to mark the position of the lesion and search for the sentinel lymph node at the same time. Using giant vesicle aggregates that can encapsulate a contrast agent, the lab proposes a method of switching between a function that keeps the agent in place and a function that tracks it, by means of high-intensity ultrasound.
*Illustrative imageSafety of ultrasound cavitation
In an ultrasonic coagulation-cutting device, the blade that grips tissue vibrates strongly at a frequency of about several tens of kHz, so cavitation occurs near it. Because cavitation is known to damage living tissue, the lab verifies the safety of the device from the viewpoint of cavitation.
MembersFaculty
The lab's members consist of faculty, master's and undergraduate students, and research students.
- Associate ProfessorKenji Yoshida
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “A modern medical ultrasound scanner” Harrison Keely / CC BY 4.0 (cropped)
- Highly sensitive contrast-enhanced ultrasound: “Mechanisms for Loading Microbubbles with Drug” Wolfpack bme 2022 / CC BY-SA 4.0 (cropped)
- Seeing with ultrasound and fluorescence at the same time: “Ultrasound (Sonography) Imaging Services in Navi Mumbai” Goleisureintl / CC BY 4.0 (cropped)
- Supporting treatment with giant vesicle aggregates: “Giant lipid vesicles ( )” eLife - the journal / CC BY 2.0 (cropped)
- Safety of ultrasound cavitation: “Transsonic T 310 ultrasound cleaner” W.carter / CC BY-SA 4.0 (cropped)
- Related lab (Yamaguchi Lab): “Doppler Ultrasound and Vascular Sonography Examination in Navi Mumbai, Maharashtra, India” Goleisureintl / CC BY 4.0 (cropped)
- Related lab ((Symbiosis 1) Bioprocess Chemistry Lab): “Lab-on-a-chip; Micro Microwave ( )” National Institute of Standards and Technology / Public domain (cropped)
- Related lab (Medical Bioelectromagnetics Lab (Saito Lab)): “Metallic lens antenna Bell Labs 1946” 作者不詳 / Public domain (cropped)
- Related lab (Micro-CT and Medical Imaging Engineering Lab): “X-ray Computed Tomography of Astromaterials -- jsc2024e076997” NASA Johnson Space Center / ROBERT MARKOWITZ NASA-JSC / Public domain (cropped)
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