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(Symbiosis 1) Bioprocess Chemistry Lab
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A lab that develops medically useful technologies by manipulating cells and materials inside narrow microchannels.
AboutAbout the lab
Handling cells inside narrow channels
The Bioprocess Chemistry Lab conducts research under the keywords bio, microtechnology, materials chemistry, and chemical engineering.
The lab develops new technologies useful for regenerative medicine, diagnostics, drug discovery, and the synthesis of functional materials.
It designs channels tens of micrometers wide and deep, and develops methods to sort cells and microparticles with precision.
The lab also microfabricates materials such as hydrogels to create three-dimensional structures that resemble living tissue.
Key terms
- Microfluidic device
- A plate with channels carved into it that are as thin as a hair. It can move liquids and cells precisely in tiny amounts.
- Hydrogel
- A material that holds plenty of water and becomes jelly-like. It can create an environment close to that of living tissue.
- Extracellular matrix (ECM)
- Proteins and other substances around cells that support them and serve as a scaffold.
NewsLab news
A student won the Excellent Poster Award at IMRET18
A student won the Bio Division Outstanding Poster Award at the 57th Autumn Meeting of the Society of Chemical Engineers, Japan (SCEJ)
A student won the Outstanding Student Award and the Special Student Award at the SCEJ Chiba Meeting 2026
A student won a Poster Award at YABEC2025
A student won the Outstanding Student Award and the Special Student Award at the SCEJ Hachinohe Meeting 2025
ResearchResearch themes
Building on microfabrication and microfluidic devices, the lab develops new methods for handling cells and materials. It aims for technologies that lead to regenerative medicine, diagnostics, drug discovery, and the synthesis of functional materials.
*Illustrative imageMicrofabrication of ECM and Tissue Engineering
Using microfabrication and microfluidic devices, the lab produces microscale materials made of extracellular matrix (ECM) such as collagen and Matrigel. It also works on building structures in which multiple types of cells are arranged hierarchically, and assembling them into complex three-dimensional tissues.
*Illustrative imageCulturing Hepatocytes in Hydrogels
The liver is sometimes called the "chemical factory of the body," but when hepatocytes are removed from the body, their function and survival rate drop sharply. The lab therefore mimics the in vivo environment outside the body by building hydrogel culture systems threaded with vascular networks, aiming for applications in artificial livers and tools that support drug discovery.
*Illustrative imageSorting Cells with Microchannels
The lab develops technologies to separate and select specific cells and biological microparticles from complex cell populations found in blood, environmental water, and culture systems. By precisely designing channels tens of micrometers wide and deep, it aims for a mechanism that can sort accurately simply by flowing a suspension through.
High-Performance Materials Made with Laminar Flow
Using the stable laminar flow that forms inside microchannels, the lab produces functional hydrogel materials in a variety of shapes. These include fibers and sheets with anisotropic patterns in their cross-sections, and multiphase materials that encapsulate droplets.
MembersFaculty
The members of the Bioprocess Chemistry Lab consist of faculty, postdoctoral researchers, and graduate and undergraduate students.As of 2026
- ProfessorMasumi Yamada
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Lab-on-a-chip; Micro Microwave ( )” National Institute of Standards and Technology / Public domain (cropped)
- Microfabrication of ECM and Tissue Engineering: “3D printed Hydrogel Scaffold” Habannn / CC0 (cropped)
- Culturing Hepatocytes in Hydrogels: “NFC hydrogel in 384 plate” Qspheroid4 / CC BY-SA 4.0 (cropped)
- Sorting Cells with Microchannels: “Hydrodynamic flow focusing in a microfluidic device” Ihor Panas / CC BY 4.0 (cropped)
- Related lab (Shiba Lab): “CdSeNanoplatelets” Kabotin / CC BY-SA 4.0 (cropped)
- Related lab (Yoshida Lab): “A modern medical ultrasound scanner” Harrison Keely / CC BY 4.0 (cropped)
- Related lab (Neural Systems Engineering Lab (NSELab)): “Neuro-ms” Baburov / CC BY-SA 4.0 (cropped)
- Related lab (Ryu Lab): “Holding Tanks ( )” Leslie Seaton from Seattle, WA, USA / CC BY 2.0 (cropped)
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