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International Institute for Integrative Sleep Medicine (WPI-IIIS) Toda Lab
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A molecular genetics lab that uses fruit flies to explore the nature of sleepiness.
AboutAbout the lab
Fruit fly sleep research exploring the nature of sleepiness
The Toda Lab uses fruit flies to study how sleep is regulated by genes.
Sleep is a behavior widely conserved among animals, but many mysteries remain about its function and mechanisms.
Project Assistant Professor Toda discovered nemuri, a gene that induces sleep, and aims to elucidate how "sleepiness" is represented in the brain.
The lab belongs to the International Institute for Integrative Sleep Medicine (WPI-IIIS).
Key terms
- Fruit fly
- A kind of small fly. It is extremely well suited to genetic manipulation and gene searches, and is used in this lab's sleep research.
- Peptide
- A molecule made of amino acids linked in a short chain. nemuri is a secreted gene that encodes a short peptide.
- Molecular imaging
- A technique for capturing the movement and distribution of molecules as images. It is one of the methods this lab adds to its sleep research.
ResearchResearch themes
Sleep is a behavior conserved across species throughout the animal kingdom, but its genetic regulation has not been well understood until now. Adding molecular imaging and other approaches to genetic, biochemical, and behavioral methods in fruit flies, the lab aims to elucidate how "sleepiness" is represented in the brain.
*Illustrative imageSearching for Genes That Induce Sleep
Using a sleep behavior assay in fruit flies, Project Assistant Professor Toda screened more than 12,000 lines for genes that induce sleep. This led to the successful identification of a new gene.
*Illustrative imageNemuri: A Gene Linking Sleep and Immunity
nemuri is a secreted gene that encodes a short peptide. It has antimicrobial activity and plays an important role in sleep during bacterial infection, so it is considered a gene that links sleep and immunity. To examine whether it is conserved in mammals, the lab will attempt to comprehensively express human genes in fruit flies.
MembersFaculty
The Toda Lab has members in a range of roles, including undergraduate students, graduate students, laboratory assistants, and postdoctoral researchers.
- Project Assistant ProfessorHirofumi Toda
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Drosophila vials” J. Albert Vallunen (albval) / CC BY-SA 2.5 (cropped)
- Searching for Genes That Induce Sleep: “Culture vials of Drosophila melanogaster in Unifei” Mateus S. Figueiredo / CC BY 4.0 (cropped)
- Nemuri: A Gene Linking Sleep and Immunity: “Drosophila melanogaster 53362116” Alexis / CC BY 4.0 (cropped)
- Related lab (国際統合睡眠医科学研究機構(WPI-IIIS) グリーン／フォークト研究室): “Unbonnetalectrodes” Simon Fraser University - Communications & Marketing / CC BY 2.0 (cropped)
- Related lab (国際統合睡眠医科学研究機構(WPI-IIIS) 柳沢／船戸研究室): “Mother and newborn sleeping on a bamboo bed near a campfire in a house in Don Det Laos” Basile Morin / CC BY-SA 4.0 (cropped)
- Related lab (国際統合睡眠医科学研究機構(WPI-IIIS) 阿部研究室): “International Institute for Integrative Sleep Medicine, Jan 06, 2017” Keiina / CC BY-SA 4.0 (cropped)
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