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Optical Medical Imaging Lab
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A lab that uses optical coherence tomography to look inside living tissue.
AboutAbout the lab
Visualizing the inside of the body with light
The Optical Medical Imaging lab conducts research on creating images of the inside of living tissue using optical measurement such as optical coherence tomography (OCT).
It began in 1999 as a research group within the Applied Optics lab at the University of Tsukuba, and became independent in 2007.
Its current research covers optical coherence tomography, Jones matrix tomography, ophthalmic and dermatological imaging using these techniques, and 3D polarization microscopy.
On the lab's website, it is presented under the name "Computational Optics Group."
Key terms
- Optical coherence tomography
- An optical measurement technique that captures cross-sectional images of the inside of living tissue without damaging it. Abbreviated as OCT.
- Jones matrix
- A matrix that represents all the optical properties of a material. In optics, it is usually learned as a representation of polarization properties.
- Dynamic OCT
- A method that visualizes the activity of cells and tissue from the pixel-by-pixel temporal changes in successive OCT images.
NewsLab news
A doctoral student published a paper on a new dynamic OCT method
A Project Associate Professor published a paper on OCT image formation theory and computational aberration correction
A collaborator published a paper on an AI method that synthesizes polarization images from OCT images
Collaborators published a paper on an image formation theory that describes OCT and microscopes in a unified way
A master's student published a paper on a simulation platform for dynamic OCT
ResearchResearch themes
The lab studies optical measurement techniques that examine living tissue without damaging it, centered on optical coherence tomography (OCT). Built around Jones matrix tomography, it works on clinical applications in ophthalmology and dermatology, visualization of cellular activity, and more.
*Illustrative imageJones matrix tomography
This technology (JM-OCT) grew out of a theory that unifies the various functionally extended forms of OCT. It measures the three-dimensional distribution of the Jones matrix of biological tissue to examine the tissue's optical properties.
*Illustrative imageDynamic OCT for visualizing cellular activity
The lab analyzes temporal changes across successive OCT images to visualize the activity of cells and tissue. It proposes metrics that assess, without labels and noninvasively, the speed and occupancy of scatterers moving inside cells.
*Illustrative imageCellular-level imaging of the eye and aberration correction
The lab built an OCT image formation theory that explicitly includes optical aberrations, and designed a filter that computationally corrects image blur. It reports that this made it possible to image the living human eye at the cellular level.
*Illustrative imageOCT image formation theory
Developed by a collaborator, this theory describes exactly, without approximation, how OCT images are formed, using a four-dimensional frequency space in which the optical frequency is the fourth dimension. It can handle aberration and dispersion at the same time.
MembersFaculty
The members of the Optical Medical Imaging lab consist of faculty, doctoral, master's, and undergraduate students, exchange students, a research support team (administration and research management), collaborators, and alumni.As of 2024
- ProfessorYoshiaki Yasuno
- Project Associate ProfessorShuichi Makita
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Working at an optical communications system testbed” NiamhTalking90 / CC BY-SA 4.0 (cropped)
- Jones matrix tomography: “Nd-YAG laser” Thctamm / CC BY-SA 3.0 (cropped)
- Dynamic OCT for visualizing cellular activity: “Optical Coherence Tomography of optic nerve and surrounding retina” Bobjgalindo / CC BY-SA 4.0 (cropped)
- Cellular-level imaging of the eye and aberration correction: “Retinal detachment LogMAR chart B” Stewart Lamb Cromar / CC BY 2.0 (cropped)
- OCT image formation theory: “Femtosecond Laser and Pulse Compressor - Optics Lab - INRIM” Giorgio Brida from Torino, Italy / CC BY 2.0 (cropped)
- Related lab (Medical Mathematical Informatics Lab): “Laptop and stethoscope ( )” jfcherry / CC BY-SA 2.0 (cropped)
- Related lab (Breast and Endocrine Surgery Lab): “Breast Cancer Awareness Month, early detection saves lives 161017-F-JC454-002” Staff Sgt. Teresa Cleveland / Public domain (cropped)
- Related lab (Bioinformatics Lab): “Eppendorf epMotion 5075 liquid handling robot” Magnus Manske / CC BY-SA 3.0 (cropped)
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