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Metabolism, Endocrinology and Diabetes Lab
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A lab that uses patients' concerns as clues to explore the mechanisms of metabolism and endocrinology.
AboutAbout the lab
Walking on fresh snow, in both clinical care and research.
The Metabolism, Endocrinology and Diabetes Lab conducts research and clinical care on endocrine and metabolic diseases such as diabetes and metabolic syndrome.
Its strength is that it finds starting points for research in the care of patients, applies them to basic research, and can ultimately develop them into applied research that benefits patients.
In basic research, each group investigates the functions of molecules involved in metabolism and endocrinology, including CtBP2, a molecule that senses metabolites.
Undergraduate students can take part in research through lab practicums and the New Medical Sciences program, and graduate students through degree programs such as the Degree Programs in Medical Sciences.
Key terms
- CtBP2
- A transcriptional repressor with a pocket structure that binds metabolites. Its activity changes depending on the metabolite it binds
- Transcription factor
- A protein that regulates how much a gene is expressed
- Elovl6
- A fatty acid elongase that uses saturated and monounsaturated fatty acids with 12 to 16 carbons as substrates
- Trans-omics network
- An information network formed by the coordinated action of omics data from different layers, such as the transcriptome
NewsLab news
View More ↗ResearchResearch themes
The lab believes that nucleic acids, lipids, and metabolism strongly influence almost all biological phenomena, and it studies metabolism and endocrinology broadly. In basic research, the Sekiya, Osaki, Matsuzaka, and Miyamoto groups each focus on their own molecules and networks.
*Illustrative imageThe function of CtBP2, a metabolite sensor
CtBP2 is a transcriptional repressor whose activity changes depending on the metabolite it binds. The lab found that in obesity, fatty acyl-CoA binds to CtBP2 and inactivates it, which increases the expression of genes related to metabolic syndrome.
*Illustrative imageCholesterol synthesis and the transcription factor CREBH
The lab uses mice deficient in HMGCR, an enzyme of cholesterol synthesis, to study issues such as the side effects of statins. It also analyzes how CREBH, a transcription factor in the small intestine and liver, affects nutrient metabolism and non-alcoholic fatty liver disease.
*Illustrative imageFatty acid quality and energy metabolism
The lab studies how the "quality" of lipids, such as fatty acid chain length and degree of unsaturation, relates to energy metabolism and lifestyle-related diseases. It analyzes genetically modified mice for Elovl6, a fatty acid elongase, and others, aiming to develop methods of prevention and treatment.
*Illustrative imageVisualizing networks that respond to metabolism
The lab defines the process by which changes in metabolic information lead to specific outputs as a "metabolism-responsive trans-omics network." It combines omics analysis and information visualization with the development of Programmable Biocomputing Devices to try to clarify the whole picture.
MembersFaculty
Members of the Metabolism, Endocrinology and Diabetes Lab are faculty members, professors emeriti, specialty residents, PhD and master's students, undergraduate students, technical assistants and technical staff, secretaries, and collaborators.As of 2026
- ProfessorMotohiro Sekiya
- ProfessorTakashi Matsuzaka
- Associate ProfessorTakafumi Miyamoto
- LecturerHitoshi Iwasaki
- LecturerYoshinori Osaki
- Hospital LecturerYoko Kanno
- Hospital LecturerTomoki Murayama
- Hospital LecturerTakaaki Matsuda
- Hospital Assistant ProfessorNako Matsumoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Self Monitoring of Blood Glucose” Omstaal / CC BY-SA 4.0 (cropped)
- The function of CtBP2, a metabolite sensor: “NAD+ Metabolism and Epigenetic Regulation of Pluripotency” Ludovic Zimmerlin, Elias Zambidis / CC BY-SA 4.0 (cropped)
- Cholesterol synthesis and the transcription factor CREBH: “Liver reticulin” Nephron / CC BY-SA 3.0 (cropped)
- Fatty acid quality and energy metabolism: “Nonacosylic-acid-3D-balls” Jynto and Ben Mills / Public domain (cropped)
- Visualizing networks that respond to metabolism: “Mass spectrometer quadrupole” Fulvio314 / CC BY-SA 3.0 (cropped)
- Related lab (Clinical Laboratory Medicine Lab): “Clinical Chemistry Analyzer , Клинички биохемиски анализатор 3” Делфина / CC BY-SA 4.0 (cropped)
- Related lab (Cardiovascular Medicine Lab): “Medical Equipment at Government General Hospital Mahbubnagar Telangana” Kavali Chandrakanth KCK / CC BY-SA 4.0 (cropped)
- Related lab (Social Health Medicine Lab): “Community health fair improves healthcare accessibility on St Kitts, Nevis (8978317)” U.S. Air Force photo by Maj. Stephani Schafer / Public domain (cropped)
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