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Bioorganic Chemistry Lab
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The lab aims to elucidate the functions of natural products using organic chemistry and biochemistry.
AboutAbout the lab
Exploring the functions of natural products with the power of chemistry
The Bioorganic Chemistry Lab uses the knowledge and techniques of organic chemistry and biochemistry to elucidate the functions of natural products that show distinctive biological activity.
In particular, it targets bioactive natural products produced by marine organisms and microorganisms, and takes on the question of why they show biological activity.
Using the total synthesis of natural products as a foothold, the lab investigates the relationship between structure and biological activity, as well as the mechanisms of action.
The main research subjects are cyclic peptides and natural products involved in protein-protein interactions.
Key terms
- Natural product
- A secondary metabolite produced by living organisms. Many natural products are compounds that show biological activity
- Total synthesis
- Artificially building a complex, naturally occurring compound by combining chemical reactions
- Cyclic peptide
- A peptide in a ring shape. It has higher stability in vivo and higher membrane permeability than a linear one
- Protein-protein interaction
- The binding of proteins to one another. It is involved in various kinds of signal transduction in living organisms
NewsLab news
Associate Professor Keisuke Fukaya received the Encouragement Award from the Natural Products Chemistry Colloquium
Paper accepted in Chem. Pharm. Bull.
A doctoral student received the Student Presentation Award at the 106th Spring Annual Meeting of the Chemical Society of Japan
Paper accepted in Chem. Pharm. Bull.
ResearchResearch themes
Many natural products show biological activity that could be applied to pharmaceuticals and agrochemicals, but why they show this activity is often poorly understood. Using the power of organic chemistry and biochemistry, the lab aims to elucidate the functions of bioactive natural products, especially those produced by marine organisms and microorganisms.
*Illustrative imageStructure and Biological Activity of Cyclic Peptides
Cyclic peptides have higher stability in vivo and higher membrane permeability than linear ones, and are attracting attention in drug development. Building on the total synthesis of natural cyclic peptides, the lab investigates the relationship between the cyclic structure and biological activity, as well as the mechanism of action.
*Illustrative imageNatural Products Involved in Protein-Protein Interactions
Protein-protein interactions are involved in signal transduction in living organisms and are attracting attention as targets for new drug discovery. For natural products that induce or block these interactions, the lab uses total synthesis and structure-activity relationship studies as a foothold, aiming to elucidate their mechanisms of action and establish methods for analyzing them.
*Illustrative imageIsolation, Structure Determination, and Total Synthesis of Bioactive Natural Products
The lab searches for new natural products derived from marine organisms, using biological activity as an indicator. For the natural products obtained, it considers total synthesis in order to move on to bioorganic chemistry research.
MembersFaculty
The members of the Bioorganic Chemistry Lab are faculty, professors emeriti, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorMasahito Yoshida
- Associate ProfessorKeisuke Fukaya
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Separatory funnel” 作者不詳 / Public domain (cropped)
- Structure and Biological Activity of Cyclic Peptides: “Cyclic peptide ipglycermide” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Natural Products Involved in Protein-Protein Interactions: “Structure of TAZ-TEAD complex (Mouse) - Protein Data Bank” Protein Data Bank (PDB) / CC0 (cropped)
- Isolation, Structure Determination, and Total Synthesis of Bioactive Natural Products: “Styela clava” This photo has been taken by Matthieu Sontag (User:Mirgolth) and released under the licenses stated below. You are free to use it for any purpose as long as you credit me as author, Wikimedia Commons as site and follow the terms of the licenses. Could you be kind enough to leave me a message on this page to inform me about your use of this picture. / CC BY-SA 3.0 (cropped)
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