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Metabolic Regulation and Pharmaceutical Sciences Lab
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A lab that studies the metabolism of trace elements and reactive species to contribute to drug discovery.

AboutAbout the lab
Understanding the metabolism of trace elements and reactive species at the molecular level and applying ways to control it to drug discovery
The lab focuses on the roles of trace elements in the body and studies at the molecular level how they protect against reactive oxygen species, which are highly reactive, and toxic substances.
Previous research has shown that abnormal metabolism of trace elements is linked to diabetes, cancer, and neurodegenerative diseases.
Based on methods from biochemistry and molecular biology, the lab uses genetically modified animals and model cells to conduct research that leads from the identification of disease biomarkers to the development of therapies.
The lab is recruiting undergraduate, master's, and doctoral students who aspire to become researchers.
Key terms
- Trace elements
- Elements that make up less than 1% of the body overall. They play an important role in maintaining whole-body homeostasis.
- Reactive oxygen species
- Highly reactive forms of oxygen generated from part of the oxygen used to produce energy through respiration. They oxidize and denature biomolecules.
- Biomarker
- An indicator in the body that serves as a guide to whether a disease is present and how far it has progressed.
ResearchResearch themes
The lab aims to understand the metabolism of trace elements and reactive species at the molecular level and to apply ways to control it to drug discovery. Based on methods from biochemistry and molecular biology, the lab incorporates genetically modified animals, model cells, and comprehensive analytical approaches into its research.
*Illustrative imageRoles of trace elements and drug discovery
The lab investigates at the molecular level how trace elements, which account for less than 1% of the body overall, maintain whole-body homeostasis, focusing on their protective action against reactive oxygen species and toxic substances. Links to diabetes, cancer, and neurodegenerative diseases have also become clear.
*Illustrative imageReactive oxygen balance and cellular responses
Reactive oxygen species oxidize and denature biomolecules, but they also act as signaling molecules in cellular responses. Both too much and too little have effects, so the lab studies this balance, as well as the heavy metals, toxic substances, and nutritional deficiencies that disrupt it.
MembersFaculty
The members of the Metabolic Regulation and Pharmaceutical Sciences Lab are faculty members, postdoctoral researchers of the Japan Society for the Promotion of Science, research assistants, research support staff, doctoral and master's students, and undergraduate students from the Department of Pharmaceutical Sciences and the Department of Drug Discovery Science.As of 2025
- ProfessorYoshiro Saito
- Associate ProfessorTakashi Toyama
- Assistant ProfessorKota Noritsugu
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Biochemistry laboratory at the Cawthron Institute, Nelson, around 1949” not stated / Public domain (cropped)
- Roles of trace elements and drug discovery: “Iodine pills” Mx. Granger / CC0 (cropped)
- Reactive oxygen balance and cellular responses: “Fluoromethylidyne radical spacefill” Jynto (more from this user) / CC0 (cropped)
- Related lab (生物構造化学分野): “Optical microscope for the study of paint fragments” Froselong / CC BY-SA 4.0 (cropped)
- Related lab (環境調和化学分野): “BuretteFumeHood” Walkerma / CC BY-SA 3.0 (cropped)
- Related lab (病態分子薬学分野): “Ion chromatograph in combination with a mass spectrometer, in CAFIA laboratory, Czech Republic” Sarka Na kopci / CC BY-SA 4.0 (cropped)
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