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Neuropathophysiology and Control Lab
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A lab that develops new treatments from clinical challenges in neurosurgery.
AboutAbout the lab
Developing new treatments from bedside challenges.
The Neuropathophysiology and Control Lab was founded in May 2018 with the aim of developing cutting-edge treatments in neurosurgery.
Working with the neurosurgery department, the lab identifies what is needed at the bedside and turns it into themes for developing new treatments.
The Professor and the Associate Professor are neurosurgeons who currently perform surgery, so the environment lets students work through the whole process, from finding problems to development and clinical application.
The lab belongs to both the Graduate School of Biomedical Engineering and the Graduate School of Medicine, and students earn a master's or doctoral degree in biomedical engineering or medicine depending on the graduate school they enter.
Key terms
- Muse cells
- Repair stem cells that exist naturally in the body. They have pluripotency, the ability to become various types of cells, and are unlikely to form tumors
- SMTP
- A unique group of compounds that combine effects such as dissolving blood clots and suppressing inflammation
- Computational fluid dynamics
- Originally an engineering technique, a method of investigating the flow of liquids and gases by calculating it on a computer
NewsLab news
The division names were changed to “Neural Reconstruction Biomedical Engineering” and “Neuropathophysiology and Control”
Clinical trial results for TMS-007, a drug co-developed with Tokyo University of Agriculture and Technology and TMS, were published in Stroke
The world's fastest fluorescence lifetime microscope was developed in an international collaboration with the University of Tokyo
A graduate student received the Best Presenter Award at the poster session of a workshop on technologies supporting young researchers
A review article by the Professor and colleagues on coil embolization of wide-neck bifurcation aneurysms was published in an academic journal
ResearchResearch themes
Starting from what is needed in clinical neurosurgery, the lab works on developing new treatments and medical technologies for neurological diseases such as cerebral infarction. Its wide range of themes, from basic research to clinical translation, includes stem cell therapy, new drugs, bone regeneration materials, and analysis of blood vessels by computational fluid dynamics.
*Illustrative imageStem cell therapy for cerebral infarction with Muse cells
The lab administers Muse cells to animal models of cerebral infarction and examines improvement in neurological symptoms and changes in tissue to find ways to enhance the effect. From 2018 to 2021, a clinical trial treating patients was also conducted.
*Illustrative imageDevelopment of SMTP, a drug for cerebral infarction
In collaboration with TMS Co., Ltd., the lab studies SMTP compounds, which have both thrombolytic and anti-inflammatory effects. Starting from animal experiments, a multicenter phase 2 clinical trial targeting patients such as those with cerebral infarction within 12 hours showed better neurological outcomes than the placebo group.
*Illustrative imageDevelopment of cranial bone regeneration materials
In joint experiments with professors from the Bone Regeneration Biomedical Engineering division of the Graduate School of Biomedical Engineering and from the Graduate School of Dentistry, the lab studies applying OCP/Col, a new bone regeneration material that could be described as “making bone with a sponge,” to brain diseases. The goal is to move on to clinical studies and clinical trials.
*Illustrative imageAnalysis of cerebral blood vessels by computational fluid dynamics
The lab applies computational fluid dynamics, an engineering technique, to analysis of the human body to investigate diseases involving cerebral blood vessels, such as cerebral aneurysm, carotid artery stenosis, and cerebral arteriovenous malformation. It is also used to judge prognosis and to simulate treatment.
MembersFaculty
The members of the Neuropathophysiology and Control Lab consist of faculty, graduate students, assistants, technical assistants, and secretaries. Faculty from the SiRIUS Medical Innovation Institute also join as members.As of 2025
- ProfessorKuniyasu Niizuma
- Associate ProfessorSherif Sherif
- Associate ProfessorHiroyuki Sakata
- LecturerAmami Kobayashi
- Assistant ProfessorHiroshi Kanno
- Project Assistant ProfessorDaisuke Ando
- Assistant (Joshu)Michihisa Watanabe
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ipswich Hospital operating theatre, Queensland, 2022 02” Kgbo / CC BY-SA 4.0 (cropped)
- Stem cell therapy for cerebral infarction with Muse cells: “Pipette gallery” User:Squidonius, myself, and User:Beliason (assumed). / CC BY-SA 4.0 (cropped)
- Development of SMTP, a drug for cerebral infarction: “Blood clot 2” Yale Rosen / CC BY-SA 2.0 (cropped)
- Development of cranial bone regeneration materials: “CTSkullImage - cropped” Sjschen at English Wikipedia / Public domain (cropped)
- Analysis of cerebral blood vessels by computational fluid dynamics: “Cerebral angiography, arteria vertebralis sinister injection” Lipothymia / Public domain (cropped)
- Related lab (Ophthalmology Lab): “Ophthalmological Checking Up” Mahmoud Amer / CC BY-SA 4.0 (cropped)
- Related lab (Neurosurgery Lab): “Operating-room 1” 연세건우병원 / CC BY 4.0 (cropped)
- Related lab (Plastic and Reconstructive Surgery Lab): “Facial plastic surgery procedure in operating room” FacialAnatomyEditor / CC BY 4.0 (cropped)
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