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Clinical Pharmaceutical Sciences Lab
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A hospital-based lab that uses mass spectrometry to explore disease biomarkers and how drugs work in the body.
AboutAbout the lab
Uncovering disease mechanisms and causes at the molecular level to create personalized medicine.
Taking advantage of being located inside a hospital, the lab conducts research on providing safe, high-quality drug therapy and on elucidating how diseases arise.
Building on liquid chromatography and mass spectrometry as core technologies, the lab develops highly sensitive methods for measuring molecules and drugs in the body, aiming to establish early diagnostic methods for diseases and to optimize drug therapy for each individual.
The lab also conducts many joint studies with other labs in the Graduate School of Medicine and the Graduate School of Pharmaceutical Sciences, as well as with clinical departments and pharmacists at the university hospital.
The lab is a cooperating division of Pathological Molecular Pharmaceutics in the Graduate School of Pharmaceutical Sciences and of Clinical Pharmaceutical Sciences in the Graduate School of Medicine.
Key terms
- Biomarker
- A substance in the body that is characteristic of a disease. It is used as a marker for diagnosis and for early detection of adverse drug events.
- Liquid chromatography-tandem mass spectrometry
- An analytical method that separates a mixture into its components and measures their masses to determine the types and amounts of substances.
- Pharmacoepidemiology
- The study of the relationship between drug use and health outcomes, using data from large numbers of people.
- GWAS
- An analysis that examines associations between genetic differences across the whole genome and traits such as diseases.
NewsLab news
A doctoral student received the Student Excellent Presentation Award at the 68th Annual Meeting of the Japanese Conference on the Biochemistry of Lipids
A student received the Student Excellent Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
A paper by a doctoral student was published in Journal of Pharmaceutical and Biomedical Analysis Open
An undergraduate student received the Student Award at the 65th Annual Meeting of the Japan Society of Clinical Chemistry
ResearchResearch themes
Taking advantage of being located inside a hospital, the lab conducts research to provide patients with safe, high-quality drug therapy. Each faculty member works on topics such as biomarker discovery and adverse drug events, personalized medicine, and the effects of drugs on pregnant women and their children.
*Illustrative imageDisease Biomarkers and Adverse Drug Events
Through joint research with many researchers, including clinicians and basic medical researchers, the lab elucidates disease mechanisms and searches for biomarkers for early diagnosis, prognosis prediction, and early detection of adverse drug events. Using liquid chromatography-tandem mass spectrometry, it studies conditions such as Niemann-Pick disease type C and kidney cancer.
*Illustrative imageBasic and Clinical Research Toward Personalized Medicine
To address individual differences in drug efficacy and side effects, the lab aims for personalized drug therapy that gives each patient the optimal drug at the optimal dose. It studies biomarkers that predict drug-metabolizing enzyme activity, methods for measuring drug concentrations in blood, and biomarkers for early detection of drug-induced liver injury.
*Illustrative imageResearch on the Effects of Drugs on Pregnant Women and Their Children
Information on the safety of drug use in pregnant women and children is lacking, because such information cannot be obtained during drug development and the foundation for evaluation is limited. The lab evaluates safety through birth cohort studies and pharmacoepidemiologic studies using databases of insurance claims and electronic medical records.
*Illustrative imageAnalysis of Genetic Factors Incorporating Family Information
In genome-wide association studies (GWAS) of the general population, it has been reported that associations weaken when family information is taken into account, which suggests that effects may be overestimated. The lab conducts research to accurately extract genomic factors involved in the onset of diseases and adverse drug reactions through analyses that incorporate family information.
MembersFaculty
The lab's members consist of faculty, concurrently appointed faculty, lab researchers, and doctoral and undergraduate students.As of 2026
- ProfessorNariyasu Mano
- Associate ProfessorMasamitsu Maekawa
- Assistant ProfessorRyosuke Segawa
- Assistant ProfessorMasaki Kumondai
- Associate Professor (Concurrent)Mayumi Sato
- Professor (Concurrent)Taku Obara
- Assistant Professor (Concurrent)Aoi Noda
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Agilent LC-MS” Nick Birse / CC BY-SA 4.0 (cropped)
- Disease Biomarkers and Adverse Drug Events: “Clinical Chemistry Analyzer , Клинички биохемиски анализатор 3” Делфина / CC BY-SA 4.0 (cropped)
- Basic and Clinical Research Toward Personalized Medicine: “Common Diabetes oral medication” Joekyabby1 / CC BY-SA 4.0 (cropped)
- Research on the Effects of Drugs on Pregnant Women and Their Children: “Mother and her baby girl, Moscow Oblast, Russia” Vyacheslav Argenberg / CC BY 4.0 (cropped)
- Analysis of Genetic Factors Incorporating Family Information: “Preparing Samples for DNA Extraction ( )” U. S. Fish and Wildlife Service - Northeast Region / Public domain (cropped)
- Related lab (Genomic Medicine and Pharmaceutical Sciences Lab (Graduate School of Pharmaceutical Sciences)): “DNA translation example” U.S. Department of Energy Human Genome Program / Public domain (cropped)
- Related lab (Respiratory Medicine Lab): “COR-2-STND-CHEST-LUNGS” Ptrump16 / CC BY-SA 4.0 (cropped)
- Related lab (Psychiatry Lab): “Babcock Building, Former South Carolina State Hospital, Columbia, SC” w_lemay / CC BY-SA 2.0 (cropped)
- Related lab (Ophthalmology Lab): “Ophthalmological Checking Up” Mahmoud Amer / CC BY-SA 4.0 (cropped)
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