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Aging Biology Lab (Institute of Development, Aging and Cancer)
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The lab investigates the fundamental nature of aging through the microbiome and the immune system.
AboutAbout the lab
Uncovering the essence of aging through bacteria, immunity, and cellular senescence
The lab studies how the communities of microorganisms that live symbiotically in the human body (the microbiome) affect aging through the immune system.
From many angles, the lab analyzes how changes in the bacteria living in the gut, mouth, and skin cause immune aging and cellular senescence, leading to a decline in tissue function.
The lab's ultimate goal is to extend healthspan by regulating the microbiome and the immune system.
Key terms
- Microbiome
- The community of microorganisms that live symbiotically in parts of the body such as the gut, mouth, and skin
- Cellular senescence
- The state in which cells have aged. It has been suggested that the accumulation of senescent cells in tissues leads to chronic inflammation
- Healthspan
- The period during which a person can live daily life in good health, unhindered by illness or decline
ResearchResearch themes
The lab works to elucidate in detail the mechanisms by which the microbial communities that live symbiotically in the body affect aging through the immune system. Viewing aging as the result of interactions among the microbiome, the immune system, and cellular senescence, the lab aims to contribute to creating new interventions to extend healthspan.
*Illustrative imageGut bacteria, immunity, and senescent cells
The lab investigates how gut bacteria regulate immune balance throughout the body and are involved in the clearance and accumulation of senescent cells. It aims to clarify the role of gut bacteria as a command center.
*Illustrative imageOral bacteria and aging of distant tissues
The lab pursues the pathological links by which chronic inflammation caused by bacteria in the mouth leads to cellular senescence and age-related diseases in distant tissues.
*Illustrative imageSkin bacteria and cellular senescence
Using the skin, the interface with the external environment, as a model, the lab aims to identify the molecular mechanisms by which symbiotic bacteria act directly on cellular senescence.
MembersFaculty
- ProfessorShimpei Kawamoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Microbiology cabinet” Luis Fernando Flores LAB / CC BY-SA 4.0 (cropped)
- Gut bacteria, immunity, and senescent cells: “Lactobacillus spp.” No machine-readable author provided. Riccardoariotti assumed (based on copyright claims). / CC BY-SA 3.0 (cropped)
- Oral bacteria and aging of distant tissues: “Streptococcus mutans 01” Photo Credit: Content Providers(s): Streptococcus mutans Transwiki approved by: w:en:User:Dmcdevit / Public domain (cropped)
- Skin bacteria and cellular senescence: “Staphylococcus epidermidis-blood agar-detail” Pavel Dušek, vyfotografováno s laskavým svolením zaměstnanců Ústavu imunologie a mikrobiologie 1. LF UK / CC BY-SA 3.0 (cropped)
- Related lab (Pediatric Pathophysiology Lab): “Visit of Stella Kyriakides, European Commissioner, to the Bambino Gesù Children's Hospital - 2024” Elisabetta Villa / European Union, 2024 / EC - Audiovisual Service / CC BY 4.0 (cropped)
- Related lab (Emergent Medicine Lab (SiRIUS Institute of Medicine)): “Barbara McClintock ( ) shown in her laboratory in 1947” Smithsonian Institution/Science Service; Restored by Adam Cuerden / Public domain (cropped)
- Related lab (Health Policy Lab (Tohoku Medical Megabank Organization)): “Unveiling of policy to facilitate the return of health workers who have been out of service (37)” The President's Office, Maldives / CC BY 4.0 (cropped)
- Related lab (Cardiovascular Surgery Lab): “Operating theatre” Piotr Bodzek, MD / CC BY-SA 3.0 (cropped)
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