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Integrative Physiology Lab (Institute of Development, Aging and Cancer)
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The lab explores the relationship between brain aging and lifespan, focusing on the hypothalamus.
AboutAbout the lab
Exploring the mechanisms of lifespan through brain aging.
The lab studies how "brain aging," the decline in brain function that occurs with age, is involved in lifespan.
In particular, it aims to clarify the role of the hypothalamus, a region of the brain, by investigating it from the molecular level to the tissue level.
The lab also works with experts in epidemiology, clinical medicine, and mathematical modeling to develop new ways to extend healthy life expectancy in humans.
The lab is one of the research divisions of the Institute of Development, Aging and Cancer.
Key terms
- Brain aging
- The decline in brain function that occurs with age. It is suggested that it may determine lifespan itself.
- Hypothalamus
- A part of the brain. This lab focuses on its role in controlling aging and lifespan.
- Functional network
- The connections formed when multiple regions of the brain work together.
ResearchResearch themes
Brain aging that occurs with age is suggested to be more than a simple age-related phenomenon, and it may determine lifespan itself. This lab aims to understand brain aging from the molecular level to the tissue level and to clarify the role of the brain, especially the hypothalamus, in controlling aging and lifespan in mammals.
*Illustrative imageThe Relationship Between Brain Aging and Lifespan
The lab seeks to understand brain aging from the molecular level to the tissue level and investigates how the brain, especially the hypothalamus, is involved in controlling lifespan in mammals. It also works with experts in epidemiology, clinical medicine, and mathematical modeling.
*Illustrative imageHypothalamic Decline, Sleep, and Systemic Aging
When hypothalamic function declines with age, sleep quality falls and abnormalities arise in the brain's functional networks. The lab is outlining a pathway in which this induces aging phenomena throughout the body and ultimately affects lifespan.
MembersFaculty
- ProfessorAkiko Sato
- Assistant ProfessorTakumi Urushibata
- Assistant ProfessorShogo Tsuji
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Sex in MRI scan” Χαράλαμπος Γκούβας (Harrygouvas) / CC BY-SA 3.0 (cropped)
- The Relationship Between Brain Aging and Lifespan: “Elderly refugee portrait captured in Khazer frontline camp. Northern Iraq, Western Asia-2. 10 November, 2016” Mstyslav Chernov / CC BY-SA 4.0 (cropped)
- Hypothalamic Decline, Sleep, and Systemic Aging: “Bedroom of guesthouse” Fquasie / CC BY-SA 4.0 (cropped)
- Related lab (Pediatric Pathophysiology Lab): “Visit of Stella Kyriakides, European Commissioner, to the Bambino Gesù Children's Hospital - 2024” Elisabetta Villa / European Union, 2024 / EC - Audiovisual Service / CC BY 4.0 (cropped)
- Related lab (Emergent Medicine Lab (SiRIUS Institute of Medicine)): “Barbara McClintock ( ) shown in her laboratory in 1947” Smithsonian Institution/Science Service; Restored by Adam Cuerden / Public domain (cropped)
- Related lab (Health Policy Lab (Tohoku Medical Megabank Organization)): “Unveiling of policy to facilitate the return of health workers who have been out of service (37)” The President's Office, Maldives / CC BY 4.0 (cropped)
- Related lab (Cardiovascular Surgery Lab): “Operating theatre” Piotr Bodzek, MD / CC BY-SA 3.0 (cropped)
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