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Next-Generation Pediatric Medicine Lab (National Center for Child Health and Development)
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A regenerative medicine lab that takes on intractable pediatric diseases using ES cells and iPS cells.
AboutAbout the lab
Exploring treatments for intractable pediatric diseases from stem cells
The lab conducts research on regenerative medicine and drug discovery using human ES cells, iPS cells, and tissue stem cells.
Targeting intractable pediatric and developmental diseases for which no treatment exists, the lab searches for drug discovery seeds using patient-derived iPS cells and develops tests to examine the effects of drugs on the liver.
Research takes place at the Center for Regenerative Medicine of the National Center for Child Health and Development in Setagaya, Tokyo.
Key terms
- ES cells
- Short for embryonic stem cells. Stem cells with the ability to become many kinds of cells, used in regenerative medicine research
- iPS cells
- Induced pluripotent stem cells. Stem cells made from cells of the body that have the ability to become many kinds of cells
- Tissue stem cells
- Stem cells found within body tissues such as bone marrow and umbilical cord blood. They are isolated and cultured to serve as material for regenerative medicine
- Investigator-initiated clinical trial
- A clinical trial in which physicians themselves, rather than a pharmaceutical company, plan and carry out the study to confirm the efficacy and safety of a drug or treatment in humans
- Drug discovery seeds
- Candidate compounds and leads that can become the basis of a new drug
ResearchResearch themes
The lab uses human ES cells, iPS cells, and tissue stem cells to study regenerative medicine and drug discovery for intractable pediatric diseases. Human ES cell research follows national guidelines, and the lab aims to demonstrate the usefulness of iPS cells for developing treatments for intractable pediatric diseases and developmental disorders that have no existing therapy.
*Illustrative imageHuman ES Cell Research
The lab conducts human ES cell research in compliance with the national guidelines on the derivation and use of human ES cells, under an ethics review committee that includes external members. In October 2019, it carried out an investigator-initiated clinical trial using hepatocytes derived from human ES cells.
*Illustrative imageTissue Stem Cell Culture and Regenerative Medicine
The lab has succeeded in culturing and expanding human tissue stem cells outside the body, and works on their isolation and identification. It holds that culture and isolation techniques become possible only after the cellular basis is elucidated through highly reproducible biological experimental systems.
*Illustrative imageDrug Discovery and Hepatotoxicity Testing Using Disease-Specific iPS Cells
The lab establishes iPS cells from patients with rare diseases and searches for drug discovery seeds. It is also building a system that differentiates iPS cells into hepatocytes to evaluate the safety of drug candidate compounds.
*Illustrative imageHepatocyte Transplantation
Living-donor liver transplantation for neonates and low-birth-weight infants poses many challenges, and the lab focuses its research on hepatocyte transplantation, which is attracting attention as a way to overcome them. Based on its results, the lab carried out Japan's first hepatocyte transplantation and is working toward clinical application.
MembersFaculty
- ProfessorAkihiro Umezawa
- Visiting ProfessorTadashi Kaname
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Human embryonic stem cells only A” Human_embryonic_stem_cells.png: (Images: Nissim Benvenisty) derivative work: Vojtech.dostal (talk) / CC BY 2.5 (cropped)
- Human ES Cell Research: “Human embryonic stem cell colony phase” Id711 at English Wikipedia / Public domain (cropped)
- Tissue Stem Cell Culture and Regenerative Medicine: “Laminar Flow Cabinet for Tissue Culture” Miles Smith / CC BY-SA 2.0 (cropped)
- Drug Discovery and Hepatotoxicity Testing Using Disease-Specific iPS Cells: “Human induced pluripotent stem cell colony ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Hepatocyte Transplantation: “MODULAR NICU WITH HEPAFILTERS” Kaveri appala / CC BY-SA 4.0 (cropped)
- Related lab (Hematology Lab): “Myeloid leukemia” Makysm / CC0 (cropped)
- Related lab (Radioisotope Center Lab): “Sale of First Radioisotope Clinton Laboratory 1946 Oak Ridge ( )” doe-oakridge / Public domain (cropped)
- Related lab (Neurosurgery Lab): “Operating-room 1” 연세건우병원 / CC BY 4.0 (cropped)
- Related lab (Obstetrics and Fetal Pathophysiology Lab): “Fetal Anomaly Ultrasound Scan in Navi Mumbai” Goleisureintl / CC BY 4.0 (cropped)
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