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Molecular Information Chemistry Lab
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A lab that applies the physiological functions of compounds and autophagy to drug discovery.
AboutAbout the lab
Probing life with small molecules, toward drug discovery.
The Molecular Information Chemistry Lab focuses on analyzing the physiological functions of small organic molecules and advancing medicinal chemistry.
The lab provides education in organic chemistry and conducts chemical biology research as its extension.
The lab invented AUTAC, a new technology that uses autophagy to remove proteins and organelles inside cells that cause disease.
It is also working to improve vancomycin, an antibiotic regarded as a last resort for treating hospital-acquired infections.
Key terms
- Autophagy
- A mechanism by which cells break down unneeded components within themselves.
- Organelle
- A small structure inside a cell, such as a mitochondrion.
- Chemical biology
- A field that uses chemical compounds as tools to study biological phenomena.
ResearchResearch themes
The lab studies how small organic compounds work in the body and extends this research to drug development. It studies methods that use autophagy to remove the causes of disease, as well as the improvement of antibiotics.
*Illustrative imageAUTAC: removing disease causes through autophagy
The lab invented AUTAC, a new technology that uses autophagy to remove proteins and organelles inside cells that cause disease. It has drawn attention from drug discovery researchers and companies.
*Illustrative imageHow autophagy breaks down bacteria
The lab studies the mechanism by which autophagy captures and degrades bacteria that have infected cells. It found that a molecule called 8-nitro-cGMP acts as a 'degradation tag'.
*Illustrative imageImproving the antibiotic vancomycin
The lab is working to improve vancomycin, regarded as a last resort for treating hospital-acquired infections. To investigate its mechanism of action, it is also developing imaging methods for observing bacteria.
MembersFaculty
- ProfessorHirokazu Arimoto
- Assistant ProfessorDaiki Takahashi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Molecular ball-and-stick model of Perflubron, overlayed with electron-density coded VdW model” Piswind / CC BY-SA 3.0 (cropped)
- AUTAC: removing disease causes through autophagy: “Fluorescence.microscope2” Bioguy10 / CC0 (cropped)
- How autophagy breaks down bacteria: “Slice from electron cryotomogram of Bdellovibrio bacteriovorus cell” Eikosi / CC BY-SA 4.0 (cropped)
- Improving the antibiotic vancomycin: “Vancomycin-from-xtal-1996-3D-balls” Ben Mills / Public domain (cropped)
- Related lab (Bioactive Molecular Dynamics Lab): “Working in the Medicinal Chemistry Lab ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Related lab (Plant Nutrition Lab): “Green rice sheaves planted in a paddy field with long shadows at golden hour in Don Det Laos” Basile Morin / CC BY-SA 4.0 (cropped)
- Related lab (Natural Products Chemistry and Biology Lab): “Thermo LC (Liquid Chromatograph) + LTQ (Linear Trap Quadrupole)” Michael Pereckas from Milwaukee, WI, USA / CC BY-SA 2.0 (cropped)
- Related lab (Food Chemistry Lab): “Bureau of Chemistry Oil, Fat, and Wax Laboratory - DPLA - f3d71e939597ba23c14e80ed6d722d1b” United States. Food and Drug Administration / Public domain (cropped)
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