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Bioactive Molecular Dynamics Lab
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A lab that takes on extending healthy life expectancy, centered on the organic chemistry of creating pharmaceuticals.
AboutAbout the lab
Taking on the extension of healthy life expectancy through chemical biology
The Bioactive Molecular Dynamics Lab researches and proposes organic chemistry approaches to creating pharmaceuticals.
Through chemical biology research, the lab aims to extend healthy life expectancy.
Combining medicinal chemistry, synthetic organic chemistry, molecular biology, cell biology, and computational chemistry, the lab carries out all of molecular design, organic synthesis, and activity evaluation.
Lab visits are welcome at any time; please contact the lab in advance.
Key terms
- Chemical biology
- A research field that uses chemical methods to investigate biological phenomena and control their functions
- Medicinal chemistry
- Organic chemistry for creating drugs, covering everything from compound design and synthesis to structural optimization
- PROTAC
- A small molecule that brings ubiquitin ligase and a target protein close together so that the target is degraded inside cells
- Protease
- An enzyme that breaks down proteins
NewsLab news
Assistant Professor Tomoshige receives the FY2026 Pharmaceutical Society of Japan Award for Young Scientists
"The Frontiers of Medical Engineering Research," with chapters co-authored by Professor Ishikawa and Assistant Professor Tomoshige, is published
Research on compounds that induce degradation of mitochondrial proteins is published in Chemical Science
A presentation by master's students wins the MCS Excellence Award at the Medicinal Chemistry Symposium
ResearchResearch themes
This lab aims to extend healthy life expectancy through chemical biology research. Students are responsible for all of the molecular design, organic synthesis, and activity evaluation of bioactive compounds themselves.
*Illustrative imageOrganic Chemistry for Creating Drugs (Medicinal Chemistry)
Medicinal chemistry is organic chemistry for creating drugs. It includes not only synthesizing compounds but also understanding interactions with target molecules, designing molecules that strengthen those interactions, and analyzing structure-activity relationships. It is an interdisciplinary field that also requires an understanding of biology and computational chemistry.
*Illustrative imagePROTACs That Degrade Disease-Related Proteins
PROTACs are small molecules that link a moiety binding the enzyme ubiquitin ligase to a moiety binding a target protein, directing the target to degradation inside cells. The lab creates small molecules that shorten the lifespan of disease-related proteins, such as proteins that cause neurodegenerative diseases.
*Illustrative imageProtein Degradation in Mitochondria
Proteins inside mitochondria are degraded by the mitochondria's own degradation machinery, so conventional targeted protein degradation could not address them. The lab developed mitoTPD, a technology that links a small molecule that activates the mitochondrial protease ClpP with a small molecule that binds a tag protein, directing the target to degradation.
*Illustrative imageMolecular Design for Drug-Like Behavior in the Body
The lab studies how to improve drug-like properties, such as water solubility and cell membrane permeability, through molecular design. It found an example in which adding a methyl group to the linker of a PROTAC strengthened its activity to degrade the target and also improved its cell membrane permeability.
MembersFaculty
The Bioactive Molecular Dynamics Lab consists of faculty members, project researchers, academic researchers, technical assistants, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorMinoru Ishikawa
- Associate ProfessorShusuke Tomoshige
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Working in the Medicinal Chemistry Lab ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Organic Chemistry for Creating Drugs (Medicinal Chemistry): “Pharmaceutical Chemistry Lab” 作者不詳 / Public domain (cropped)
- PROTACs That Degrade Disease-Related Proteins: “TMEM171 Structure Model” Bauma319 / CC BY-SA 4.0 (cropped)
- Protein Degradation in Mitochondria: “MEF cell mitochondria 2” Institute of Molecular Medicine I, University of Düsseldorf / CC BY 4.0 (cropped)
- Molecular Design for Drug-Like Behavior in the Body: “H2O Kalottenmodell und Stäbchenmodell 8126” Bin im Garten / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Information Chemistry Lab): “Molecular ball-and-stick model of Perflubron, overlayed with electron-density coded VdW model” Piswind / CC BY-SA 3.0 (cropped)
- Related lab (Nutrition Lab): “CSIRO ScienceImage 3075 Laboratory work with microcalorimeter” division, CSIRO / CC BY 3.0 (cropped)
- Related lab (Structural Chemistry of Life Lab): “Laboratory equipment of modern chemistry classroom” Belikov Maxim / CC BY 4.0 (cropped)
- Related lab (Bioorganic Chemistry Lab): “Scientist of the Astrochemistry Laboratory works with a Rotary evaporator inside the Goddard Astrobiology Analytical Laboratory. Rotary evaporator is used to dry down Antarctic ice samples” NASA Goddard Space Flight Center from Greenbelt, MD, USA / Public domain (cropped)
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