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Adaptive Exercise Medical Science Lab
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The lab investigates how exercise therapy works by studying the mechanisms of the brain and nervous system.
AboutAbout the lab
Uncovering the power of exercise through neuroscience.
The Adaptive Exercise Medical Science Lab studies exercise therapy, a core treatment in rehabilitation.
Exercise therapy differs from other treatments in that patients use their own bodies and minds, repeating movements to improve the target function.
The lab investigates the wide-ranging effects of exercise through basic neuroscience research using laboratory animals.
Students who are new to research are also taught carefully from the basics.
Key terms
- Neuromodulation
- Methods of externally regulating the activity of the brain and nerves, using stimulation, drugs, and other means
- BDNF
- Brain-derived neurotrophic factor. A protein that protects and nurtures neurons and makes their connections more adaptable
- Epigenetics
- Mechanisms that regulate whether genes are active without changing the DNA sequence
- Hippocampus
- A part deep in the brain that serves as a center of memory
ResearchResearch themes
The lab uses basic research with laboratory animals to study the brain and nerve mechanisms that underlie the effects of exercise therapy. Its main focuses are exercise therapy for diseases of the central nervous system and health promotion in older adults.
*Illustrative imageNeural modulation to enhance the effects of exercise therapy
The lab studies neuromodulation that can further strengthen the effects of exercise therapy in functional recovery training after stroke and similar conditions. It has found that very slightly weakening inhibition in the cerebral cortex increases brain-derived neurotrophic factor (BDNF), and that combining this with aerobic exercise increases it even more in motor-related areas.
*Illustrative imageHealth promotion for older adults
Using aged model animals, the lab examines the basis of exercise's power to prevent degenerative diseases such as dementia. It tracks how exercise increases neuroprotective substances in areas such as the hippocampus, along with the accompanying changes in motor function and behavior.
*Illustrative imageExercise and epigenetics
Using model mice with accelerated aging, the lab has confirmed that an exercise habit increases BDNF in the hippocampus and improves memory and learning. As a possible mechanism, it focuses on the finding that exercise activates histone acetyltransferase (HAT), an enzyme that modifies the histones around DNA to enhance gene activity.
MembersFaculty
The members of the Adaptive Exercise Medical Science Lab are faculty and doctoral, master's, and undergraduate students.As of 2025
- ProfessorHiroshi Maejima
- Assistant ProfessorYuichiro Oka
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mouse running on a standard wheel” Manuelito2021consupadre / CC BY-SA 4.0 (cropped)
- Neural modulation to enhance the effects of exercise therapy: “Double cone coil” Baburov / CC BY-SA 4.0 (cropped)
- Health promotion for older adults: “Hippocampal Neurons, stained” Ns takes photos / CC BY 4.0 (cropped)
- Exercise and epigenetics: “Nucleosome core particle 1EQZ v.4” Darekk2 using the cited above Protein Data Bank (PDB) structural data / CC BY-SA 3.0 (cropped)
- Related lab (Sports Physical Therapy Lab): “Hartschaumrolle” Finfit / CC BY-SA 3.0 (cropped)
- Related lab (Motor Control Lab (Hasegawa Lab)): “Beam and feet (close shot)” Raphael Goetter / CC BY 2.0 (cropped)
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