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Molecular Biology Lab
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The lab approaches the origins of congenital anomalies and cancer by studying how cell fate is determined.
AboutAbout the lab
Toward understanding disease, health, and life at the molecular level
The lab studies, at the molecular level, how cell fate is determined and how it is maintained.
It aims to clarify how mechanisms that are finely controlled in normal development break down and lead to disease and cancer.
Using methods such as multi-omics analysis, the lab works on congenital heart disease, lymphatic vessel disease, and the mechanisms of cancer progression.
Key terms
- Multi-omics analysis
- An analysis that comprehensively measures gene activity, DNA marks, proteins, and more, and interprets them in combination
- Epigenome
- The full set of marks that determine which genes are active without changing the DNA sequence, including chemical modifications of histones
- Plasticity
- The ability to change properties in response to the surrounding environment. In cancer cells, it is linked to malignant progression and resistance to treatment
NewsLab news
A paper by Lecturer Oikawa and colleagues was published in Biochemical and Biophysical Research Communications
A paper by Assistant Professor Hashimoto and colleagues was published in Cancers
A paper by Lecturer Oikawa and colleagues was published in Life Science Alliance
ResearchResearch themes
The lab aims to elucidate molecular mechanisms common to development, homeostasis, and disease. It studies how cell fate is determined and maintained, and the process by which the breakdown of these mechanisms gives rise to congenital anomalies and cancer.
*Illustrative imageCell fate and disease explored through multi-omics
Combining multiple omics analyses, the lab investigates how undifferentiated cells differentiate into cardiac muscle and blood vessel cells. It also studies the mechanisms that suppress the onset of heart and lymphatic diseases, and the effects of the maternal environment on the fetal epigenome.
*Illustrative imageHow cell identity is maintained and changed
The lab explores the fundamental principles by which chemical modifications of histones maintain or change the differentiated state of cells. It alters the environment around cells using microscopic structures, and also measures cell membrane tension in joint research with Kobe University.
*Illustrative imageChanges in cancer properties and new treatment strategies
Focusing on the ARF6–AMAP1 pathway, the lab studies the mechanisms of "plasticity," in which cancer changes its properties in response to its surroundings. It is also working to clarify how an immunosuppressive environment forms around cancer.
MembersFaculty
The lab's members consist of faculty, visiting researchers, administrative staff, and doctoral students.As of 2025
- ProfessorJun Takeuchi
- LecturerTsukasa Oikawa
- Assistant ProfessorAri Hashimoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Human embryonic stem cell colony phase” Id711 at English Wikipedia / Public domain (cropped)
- Cell fate and disease explored through multi-omics: “F-actin filaments in cardiomyocytes” Ps1415 / CC BY-SA 4.0 (cropped)
- How cell identity is maintained and changed: “Nucleosome 1KX5 colour coded” Zephyris at English Wikipedia / CC BY-SA 3.0 (cropped)
- Changes in cancer properties and new treatment strategies: “Heterogeneous breast tumor in 3D” Sshah74 / CC BY 4.0 (cropped)
- Related lab (Cancer Genomic Medicine Lab): “DNA Nanoball sequencing flow cell” Suspencewl / CC0 (cropped)
- Related lab (Anatomy and Embryology Lab): “Cerebellum PurkinjeCells” Sbrandner / Public domain (cropped)
- Related lab (Dermatology Lab): “Skin section” Pathologist without beard / CC BY 4.0 (cropped)
- Related lab (Plastic Surgery Lab): “Keloid - low mag” Nephron / CC BY-SA 3.0 (cropped)
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