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Toxicology Lab
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A toxicology lab that studies how animals protect themselves from chemicals and how environmental pollution affects Africa.
AboutAbout the lab
Exploring chemicals and animals, and how they interact, across species.
The Toxicology Lab studies how chemicals affect animals and humans.
The lab investigates how the mechanisms that protect living organisms from harmful substances differ among animal species, and how they have evolved.
In collaboration with research institutions in African countries, the lab also investigates how environmental pollution associated with rapid development affects wildlife, livestock, and humans.
The lab is recruiting graduate students and seeking collaborations for joint research.
Key terms
- Cytochrome P450
- A family of enzymes that break down or chemically modify chemicals that enter the body. It plays a central role in detoxification.
- Species differences
- The fact that the same chemical can have different effects on the body, and be detoxified to different degrees, depending on the animal species.
- Pollution source
- The origin of the substances causing environmental pollution. Mines and factories are among the sites investigated.
NewsLab news
A student received the Excellent Presentation Award at the Study Group on Responses to Internal and External Environments and Metabolic Enzymes
A student received the Excellent Presentation Award at the 2026 Annual Meeting of the Kanto Branch of the Japan Society for Bioscience, Biotechnology, and Agrochemistry
A student received the Excellent Presentation Award at the 8th Meeting of the Study Group on Mechanisms of Drug Toxicity
A student received the Outstanding "Enrei" Award from the Institute for the Advancement of Graduate Education, Hokkaido University
A student received the Outstanding "Enrei" Award from the Institute for the Advancement of Graduate Education, Hokkaido University
ResearchResearch themes
The lab studies the effects of chemicals on animals and humans from two angles: species differences in the mechanisms that protect the body, and environmental pollution in the field. Its subjects range from animals in Japan to wildlife in Africa.
*Illustrative imageEvolution and species differences in the mechanisms that protect the body from chemicals
The lab studies the mechanisms, including those mediated by cytochrome P450, that protect the body from harmful substances. It compares a wide range of animals, including carnivores such as Steller's sea eagles and Steller sea lions, elephants and giraffes exposed to plant toxins, livestock, amphibians, and chordates.
*Illustrative imageEffects of environmental pollution in Africa on animals and humans
The lab investigates the effects of environmental pollutants on African soil, fish, hippos and crocodiles, wild birds, livestock, and humans, with the aim of identifying pollution sources and developing guidelines for countermeasures. Joint research is carried out with research institutions in more than 10 countries and with the cooperation of local residents.
MembersFaculty
Members of the Toxicology Lab include faculty, academic researchers, specially appointed professional staff, postdoctoral researchers, administrative assistants, doctoral and undergraduate students, candidates for a doctorate by dissertation submission, and visiting trainees from partner institutions. Faculty from the Forensic Veterinary Science field, the Office of International Collaboration, and the One Health Research Center also take part in supervision.As of 2026
- ProfessorMayumi Ishizuka
- ProfessorYoshinori Ikenaka
- ProfessorShota Nakayama
- Project Associate ProfessorYared Beyene Yohannes
- Project Assistant ProfessorKanami Watanabe
- Project Assistant ProfessorNanako Hasegawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Lascar Hippopotamus (Zambezi river) ( )” Jorge Láscar from Australia / CC BY 2.0 (cropped)
- Evolution and species differences in the mechanisms that protect the body from chemicals: “Steller's Sea-Eagle - Hokkaido - Japan” Francesco Veronesi from Italy / CC BY-SA 2.0 (cropped)
- Effects of environmental pollution in Africa on animals and humans: “Pyromorphite-199476” Robert M. Lavinsky / CC BY-SA 3.0 (cropped)
- Related lab (寄生虫学教室): “Ezo Red Fox (Vulpes vulpes schrencki), 2024” MIKI Yoshihito / CC BY 2.0 (cropped)
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