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Radiation Biology Lab
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The lab studies how radiation affects cancer cells in search of new therapies.
AboutAbout the lab
Exploring how radiation and living organisms interact
The Radiation Biology Lab studies how radiation affects the bodies of living organisms, from the perspectives of both veterinary medicine and medicine.
Experiments use cultured cells and laboratory animals such as mice and rats.
The lab investigates how cancer cells respond to radiation, the environment surrounding tumors, and treatments that combine radiation with drugs.
Interested students from the Faculty of Veterinary Medicine at Hokkaido University and from the Joint Department of Veterinary Medicine with Obihiro University of Agriculture and Veterinary Medicine are welcome.
Key terms
- Oxidative stress
- A state in which cells are damaged by reactive oxygen species and similar agents. It also occurs when cells are exposed to radiation
- Tumor stroma
- The parts of cancer tissue other than the cancer cells themselves. It consists of cells of blood vessels, inflammatory cells, fibroblasts, and others
- Radiosensitizer
- A compound that makes cancer cells more sensitive to radiation and so enhances the effect of radiotherapy
NewsLab news
A student won the Young Investigator Excellent Presentation Award at the Young Researchers' Section of the Japanese Radiation Research Society
A student won the Best Poster Presentation Award at the Young Researchers' Meeting of the Japanese Society for Oxidative Stress
Lecturer Bo won the Academic Encouragement Award of the Japanese Society for Oxidative Stress
A student won an Excellent Presentation Award (oral presentation category) at the 67th Annual Meeting of the Japanese Radiation Research Society
Prof. Yasui (then Associate Professor) won the Academic Award of the Japanese Society for Oxidative Stress
ResearchResearch themes
The lab investigates the effects of radiation on living organisms using cultured cells and laboratory animals. Its main research areas are the response of cancer cells to radiation, the tumor microenvironment, and cancer treatments that combine radiation with drugs.
*Illustrative imageResponse of cancer cells to radiation
The lab examines the factors that influence the radiosensitivity of cancer cells and the underlying mechanisms, focusing on the cell cycle, cell division, energy metabolism, mitochondria, and oxidative stress responses. It also conducts basic research to enhance the effects of proton beam therapy, in collaboration with the Graduate School of Medicine.
*Illustrative imageTumor microenvironment
Cancer tissue contains tumor stroma, made up of blood vessels and inflammatory cells, as well as hypoxic regions where radiation is less effective. The lab investigates how this microenvironment changes with radiation and how it influences the response of cancer tissue to radiation.
*Illustrative imageDeveloping therapies to combine with radiation
The lab searches for target molecules that could lead to the development of radiosensitizers and of radioprotectors that protect normal tissue. In collaboration with universities, research institutes, and companies, it examines the effects of combining candidate compounds with radiation and the mechanisms behind them.
MembersFaculty
The members of the Radiation Biology Lab are faculty, administrative staff, visiting researchers, and doctoral and undergraduate students.As of 2026
- ProfessorHironobu Yasui
- LecturerTomoki Bo
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Tomotherapy nci-vol-4478-300” Rhoda Baer / Public domain (cropped)
- Response of cancer cells to radiation: “HeLa-Tubulin-HSP60-Fibrillarin-DNA” GerryShaw / CC BY-SA 4.0 (cropped)
- Tumor microenvironment: “Histopathology of tubular carcinoma, low magnification” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D. / CC0 (cropped)
- Developing therapies to combine with radiation: “Culture flasks cabinet in MPI-CBG” real name: Matylda Sęk pl.wiki: Cygaretka commons: Cygaretka / CC BY-SA 3.0 (cropped)
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