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Comparative Pathology Lab
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The lab diagnoses animal diseases under the microscope and investigates their causes and mechanisms.
AboutAbout the lab
Elucidating every aspect of disease
The Comparative Pathology Lab studies what causes animal diseases and how they develop.
The lab diagnoses diseases of various animals, including dogs, cats, chickens, cattle, and horses, by gross and microscopic examination, and applies the results to subsequent treatment and prevention.
In addition, the lab conducts experimental pathology research that clarifies the causes and mechanisms of disease through experiments.
The name of the lab reflects the belief of Dr. Koichi Ichikawa, who established it, that 'veterinary pathology is a field that also contributes to basic medicine.'
Key terms
- Non-coding RNA
- RNA that does not serve as a blueprint for proteins but plays roles such as regulating gene function
- Glanders
- An infectious disease of horses caused by bacteria. It can also be transmitted to humans
- Hemangiosarcoma
- A malignant cancer that arises from the cells that form blood vessels. It occurs frequently in dogs
ResearchResearch themes
The lab tackles the mysteries of disease through two approaches: pathological diagnosis of diseases that occur naturally in animals, and experimental pathology research that clarifies the causes and mechanisms of disease through experiments. It aims to understand the whole picture of disease, from the molecular level to the level of the whole organism.
*Illustrative imageHow Equine Herpesvirus Enters Cells
The lab studies how equine herpesvirus type 1, which causes abortion and encephalomyelitis in horses, enters the endothelial cells lining the blood vessels of the brain. It has identified MHC class I molecules as the receptor molecules that the virus uses to enter cells.
*Illustrative imageAn RNA That Helps Viruses Replicate
Using a cell line that can be differentiated into neuronal cells, the lab analyzes how equine herpesvirus type 1 infects cells. It has discovered a long non-coding RNA that promotes viral replication and is studying how it works.
*Illustrative imageInvestigating Glanders in Horses in Mongolia
As the lead institution of an international joint project (SATREPS), the lab investigated glanders, which is prevalent among horses in Mongolia, and developed a simple, highly sensitive gene detection method and a blood-based diagnostic method.
*Illustrative imageBasic Research on Canine Hemangiosarcoma
Hemangiosarcoma is a malignant cancer that is common in dogs and for which no effective treatment exists. To make it treatable, the lab is working on basic research, a field in which little progress had been made.
MembersFaculty
The members of the Comparative Pathology Lab are faculty members.
- ProfessorTakashi Kimura
- LecturerKeisuke Aoshima
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Tissue processing - Stained and mounted slides in the ubiquitous 20-slide folder” Ed Uthman / CC BY-SA 2.0 (cropped)
- How Equine Herpesvirus Enters Cells: “Iceland Horses Mare and Foal 9244” ImagePerson / CC BY 4.0 (cropped)
- An RNA That Helps Viruses Replicate: “Herpesvirus (negative staining)” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Investigating Glanders in Horses in Mongolia: “Herd of horses in Mongolia” Nrantuya / CC0 (cropped)
- Basic Research on Canine Hemangiosarcoma: “Renal angiosarcoma -- intermed mag” Nephron / CC BY-SA 4.0 (cropped)
- Related lab (公衆衛生学教室): “Culex Mosquito and Micrograph of West Nile Virus Particles” NIAID / CC BY 2.0 (cropped)
- Related lab (感染症学教室): “Red holstein cows near Josselin 01” Tsaag Valren / CC BY-SA 4.0 (cropped)
- Related lab (獣医衛生学教室): “Sheep and goats in Arkhangai Province” Bernard Gagnon / CC0 (cropped)
- Related lab (実
験動物学教室): “Hispid cotton rat (Sigmodon hispidus) - National Butterfly Center - Mission - Texas - USA” Chuck Homler d/b/a Focus On Wildlife / CC BY-SA 4.0 (cropped)
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