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Molecular Biology Lab
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A lab that uses Arabidopsis to study how translation, the process of making proteins, is regulated.
AboutAbout the lab
Uncovering how gene activity is regulated in plants
The Molecular Biology Lab uses Arabidopsis to study how gene activity is regulated in plants.
It focuses in particular on regulation at the stage of translation, in which proteins are made from the information in genes.
The lab's approach is to take interesting phenomena found in physiological studies and explain them through biochemistry and genetics.
Key terms
- Translation
- The process by which amino acids are linked together to make a protein, based on genetic information copied into mRNA
- Ribosome
- The machinery in the cell that reads mRNA and assembles proteins
- uORF
- A short open reading frame on an mRNA, located upstream of the main protein-coding reading frame. It can affect how much of the downstream protein is translated.
ResearchResearch themes
Using Arabidopsis thaliana, an annual plant in the mustard family (Brassicaceae), the lab focuses on intriguing biological phenomena and studies the regulation of gene expression involved in them. Combining physiology, biochemistry, and genetics, it uncovers the underlying mechanisms with molecular biology methods.
*Illustrative imageRibosomes That Sense the State of the Cell
The ribosome, the machinery that makes proteins, detects conditions inside the cell and stops translation, and in some cases even degrades the mRNA being translated. A key enzyme for methionine production in plants is subject to feedback regulation through this mechanism, and the lab aims to elucidate its molecular mechanism and apply it.
*Illustrative imageRegulation of Translation by Short Peptides
A short open reading frame (uORF) in the region upstream of an mRNA can affect how efficiently the downstream protein is translated. The lab aims to elucidate a new type of gene expression regulation involving peptides produced from uORFs.
MembersFaculty
- ProfessorHitoshi Onochi
- Assistant ProfessorYuta Hiragori
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Arabidopsis thal twice background” Reo On / CC BY-SA 3.0 (cropped)
- Ribosomes That Sense the State of the Cell: “Ecoli 70S ribosome pair vs gentamicin” Dcrjsr / CC BY 3.0 (cropped)
- Regulation of Translation by Short Peptides: “Ribosome mRNA translation en” LadyofHats / Public domain (cropped)
- Related lab (Genome Biochemistry Lab): “Sirex noctilio emerging” Paula Klasmer, Instituto Nacional de Tecnologia Agropecuaria, Argentina / CC BY 3.0 (cropped)
- Related lab (Gene Regulation Lab): “Sugar beet field ( )” Gilles San Martin from Namur, Belgium / CC BY-SA 2.0 (cropped)
- Related lab (Ecological Chemical Biology Lab): “Колонии плесневых грибов на питательной среде” Andrei Trigubovich / CC BY-SA 4.0 (cropped)
- Related lab (Plant Breeding Lab): “Bagged rice panicles” Desmanthus4food / CC BY-SA 3.0 us (cropped)
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