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Food Pathogenic Microbiology Lab (Tochinai Lab)
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The lab measures how animals' bodies function to investigate the safety of food and medicines.
AboutAbout the lab
Exploring disease and toxicity through evaluation of physiological function
The Food Pathogenic Microbiology Lab studies pathophysiology and toxicology based on the evaluation of animal physiological function.
The lab explores animal disease models and original techniques for evaluating physiological function that are useful for nonclinical safety studies of food and pharmaceuticals.
By combining pathological analysis with constantly changing data such as animal vital signs, the lab works to clarify the mechanisms of disease and to develop technologies for prevention and treatment.
The lab is now seeking to extend this approach to models of infections caused by food-borne microorganisms.
Key terms
- Nonclinical safety studies
- Research that uses animals and cells to confirm the safety of new drugs and foods before they are used in humans
- Animal disease models
- Laboratory animals made to show conditions closely resembling diseases of humans or animals
- 3Rs
- A principle in animal experiments that aims to replace animal use with alternative methods, reduce the number of animals used, and refine procedures to lessen suffering
NewsLab news
Paper comparing the cardiotoxicity of anticancer drugs in dogs accepted (joint work with the Veterinary Internal Medicine Lab)
Paper on the interaction between Escherichia coli and its host accepted (joint work with the Laboratory Animal Science Lab)
Paper on heart rate variability and tissue changes in aged former racehorses accepted
Paper on a new electrocardiogram analysis technique for horses accepted
Tochinai Lab established at the Food Safety Research Center
ResearchResearch themes
The lab explores disease models and original techniques for evaluating physiological function that are useful for nonclinical safety studies of food and pharmaceuticals. By combining data such as animal vital signs with pathological analysis, it aims to clarify the mechanisms of disease and to develop technologies for prevention and treatment.
*Illustrative imageNew techniques for analyzing physiological function
The lab is developing new techniques for analyzing physiological function that increase the biological information available for nonclinical safety assessment and that contribute to the 3Rs in laboratory animals.
*Illustrative imageHow circulatory function is maintained
Using livestock and animal disease models, the lab investigates how the state of the circulatory system, including the heart and blood vessels, is kept stable, and how this function breaks down.
*Illustrative imageMicrobial toxins and plant poisons
The lab studies how toxins produced by microorganisms and poisons from plants affect the animal body.
MembersFaculty
Members of the Food Pathogenic Microbiology Lab are faculty members and students in the doctoral and master's programs.As of 2026
- Associate ProfessorRyota TochinaiPublications ↗
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “SpragueDawleyRat” Jean-Etienne Minh-Duy Poirrier / CC BY-SA 2.0 (cropped)
- New techniques for analyzing physiological function: “Photoplethysmogram (PPG) signal” Peterhcharlton / CC BY 4.0 (cropped)
- How circulatory function is maintained: “Rockford thoroughbred racehorse 001” 不明
（出典 『優駿』1955年10月号。 コモンズ上 Unknown author） / Public domain (cropped) - Microbial toxins and plant poisons: “Digitalis purpurea RF” Robert Flogaus-Faust / CC BY 4.0 (cropped)
- Related lab (Veterinary Pharmacology Lab): “Small intestine low mag” Nephron / CC BY-SA 3.0 (cropped)
- Related lab (Veterinary Clinical Pathology Lab): “Cat and Dog Cuddling” SeanT313 / CC BY-SA 4.0 (cropped)
- Related lab (Food and Biological Function Models Lab): “Grazing cattle - panoramio” 伊藤善行 / CC BY-SA 3.0 (cropped)
- Related lab (Large Animal Clinical Medicine Lab): “Row of Holstein Friesian cows in Bronów” Mikinisk / CC BY-SA 4.0 (cropped)
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