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Veterinary Pharmacology Lab
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The lab explores how the body works and how drugs act, focusing on the muscles of the gastrointestinal tract and blood vessels.
AboutAbout the lab
The lab's central research theme: muscle
The Veterinary Pharmacology Lab studies how the body functions and how drugs act in mammals, including humans.
Its work centers on muscle: smooth muscle, which forms the walls of internal organs such as the stomach, intestines, and bladder, and skeletal muscle, which moves the body.
The lab seeks to uncover how muscle is repaired after injury and how muscle ages.
The lab also continues research on the actions of natural substances, such as toxins from marine organisms and components of foods.
Key terms
- Smooth muscle
- Muscle that forms the walls of organs such as the stomach, intestines, blood vessels, and bladder. It cannot be controlled voluntarily and contracts and relaxes slowly.
- Macrophage
- An immune cell that engulfs and clears away foreign substances and dead cells in the body. Macrophages are also found in the muscle layers of the gastrointestinal tract.
- Myofibroblast
- A type of cell related to fibroblasts that also has muscle-like properties. It is involved in wound healing and organ fibrosis.
NewsLab news
Study clarifies changes in gut microbiota and lipid metabolism in dogs with allergic disease
New method developed to evaluate food allergy reactions through urine tests
An Assistant Professor received the Annual Meeting Excellent Presentation Award at the 97th Annual Meeting of the Japanese Pharmacological Society
ResearchResearch themes
The lab has built its research on two pillars: studies of smooth muscle, which forms the walls of tubular internal organs, and studies of the actions of natural substances such as toxins from marine organisms and food components. From there, its work has expanded to the links between gastrointestinal motility and inflammation and immunity, and to organ fibrosis.
*Illustrative imageSmooth Muscle Function and Disease
The lab investigates, at the molecular level, the mechanisms of diseases caused by impaired contraction of smooth muscle in the gastrointestinal tract, blood vessels, bladder, and other organs. The goal is to lead to the development of new treatments.
*Illustrative imageGastrointestinal Motility and Immunity
The lab studies the interactions between smooth muscle and immune cells such as macrophages in the muscle layers of the gastrointestinal tract, and researches diseases such as motility disorders that accompany intestinal inflammation.
*Illustrative imageFibrosis: When Organs Become Stiff
Focusing on myofibroblasts, which are involved in wound healing and tissue fibrosis, the lab investigates how organs become fibrotic, drawing on its experience in smooth muscle research.
*Illustrative imageEffects of Natural Toxins and Food Components
The lab examines how substances act on the body, including toxins produced by marine organisms, components of foods such as rice bran, and compounds contained in Kampo (traditional Japanese herbal) medicines.
MembersFaculty
The members of the Veterinary Pharmacology Lab include faculty, secretaries, joint researchers in agriculture, and doctoral, master's, and undergraduate students.As of 2023
- ProfessorMasatoshi HoriPublications ↗
- Associate ProfessorTakahisa MurataPublications ↗
- Assistant ProfessorTamaki KurosawaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Small intestine low mag” Nephron / CC BY-SA 3.0 (cropped)
- Smooth Muscle Function and Disease: “Muscle Tissue Smooth ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Gastrointestinal Motility and Immunity: “Macrophage by NIAID” NIAID / CC BY 2.0 (cropped)
- Fibrosis: When Organs Become Stiff: “Cirrhosis of the liver (trichrome stain) ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Effects of Natural Toxins and Food Components: “Aplysina archeri (Stove-pipe Sponge-pink variation)” Nick Hobgood / CC BY-SA 3.0 (cropped)
- Related lab (Veterinary Reproduction and Breeding Lab): “Cows near Kiel - Maack - July 2010” Smaack / CC BY-SA 4.0 (cropped)
- Related lab (Food and Biological Function Models Lab): “Grazing cattle - panoramio” 伊藤善行 / CC BY-SA 3.0 (cropped)
- Related lab (Food Pathogenic Microbiology Lab (Tochinai Lab)): “SpragueDawleyRat” Jean-Etienne Minh-Duy Poirrier / CC BY-SA 2.0 (cropped)
- Related lab (Veterinary Physiology Lab): “Wistar rat” Janet Stephens / Public domain (cropped)
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