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Developmental Medical Sciences Lab
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A lab that studies mosquito-borne viral diseases such as dengue fever, covering everything from field surveys to vaccines.
AboutAbout the lab
Studying mosquito-borne viral diseases and vaccines
The Developmental Medical Sciences Lab studies mosquito-borne viral infections such as dengue fever and Zika fever.
It was founded as the first lab in Japan to study maternal and child health, and in 2021 Prof. Moi became its sixth head professor.
The lab's work ranges from field surveys with countries in Asia to the immune mechanisms against viruses and the development of vaccines and therapeutics.
International students are also enrolled, and the lab conducts joint research with research institutions in Japan and abroad, mainly in Asia.
Key terms
- Surveillance
- Ongoing monitoring of the occurrence and spread of a disease, used to inform control measures
- Neutralizing antibody
- An antibody that binds to a virus and prevents it from infecting cells
- Antibody-dependent enhancement (ADE)
- A phenomenon in which antibodies that should protect against a virus instead enhance infection. It is involved in severe cases of dengue fever.
NewsLab news
Paper on the co-circulation of multiple dengue virus genotypes in Vietnam accepted by Tropical Medicine and Health
Review on the current status and prospects of dengue vaccine development published in Uirusu, the journal of the Japanese Society for Virology
Master's and doctoral students win poster presentation awards at the 4th UTOPIA Symposium
Paper on HLA polymorphism and hybrid immunity in COVID-19 convalescents in Vietnam accepted by Frontiers in Immunology
Review on infectious disease control amid armed conflict in Ukraine published in Infectious Diseases
ResearchResearch themes
The lab studies the causes, prevention, and treatment of viral infections carried by arthropods such as mosquitoes, including dengue fever, Zika fever, Japanese encephalitis, and chikungunya fever. Its work ranges from field surveys across Asia to the analysis of immune responses and the development of vaccines and therapeutics.
*Illustrative imageSurveillance of mosquito-borne diseases
The lab conducts field surveys of mosquito-borne viral infections together with countries in Asia, including Thailand, Malaysia, the Philippines, Indonesia, Vietnam, and Nepal. The research aims to clarify how viruses spread in endemic areas and to apply that knowledge to infection prevention.
*Illustrative imageViral infection and immune response
The lab has examined the activity of infection-enhancing antibodies that act when a person is infected again with dengue virus or Zika virus, and has clarified part of the mechanism behind severe disease. It is now working to identify T-cell epitopes related to antibody responses, with the aim of developing effective vaccines.
*Illustrative imageDevelopment of diagnostics, vaccines, and therapeutics
The lab is developing and evaluating diagnostic methods for Japanese encephalitis, dengue fever, Zika fever, chikungunya fever, and other diseases, as well as developing model organisms used to evaluate vaccines and therapeutics. For dengue fever, it focuses on both neutralizing antibodies and antibody-dependent enhancement (ADE) of infection, and conducts research to improve vaccine design.
MembersFaculty
The members of the Developmental Medical Sciences Lab include faculty, project researchers, senior advisors, administrative assistants, technical specialist staff, part-time lecturers, visiting researchers, doctoral, master's, and undergraduate students, research students, and short-term international students.As of 2026
- ProfessorMeng Ling Moi
- Assistant Professorヨオ・シーンリアン
- Project Assistant ProfessorKazumi Haga
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Aedes Mosquito and Dengue Virus Particles” NIAID / CC BY 2.0 (cropped)
- Surveillance of mosquito-borne diseases: “Aedes aegypti mosquito” John Ragai from Petaling Jaya, Malaysia / CC BY 2.0 (cropped)
- Viral infection and immune response: “Dengue Virus Particles ( )” NIAID / CC BY 2.0 (cropped)
- Development of diagnostics, vaccines, and therapeutics: “Vaccine Vial (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (社会予防疫学教室): “Teishoku - traditional Japanese set meal at New Chitose Airport (97)” Savannah Rivka / CC BY-SA 4.0 (cropped)
- Related lab (精神保健学教室): “Bench in park” Nirmal Bhagwani / CC BY-SA 4.0 (cropped)
- Related lab (保健社会
行動学分野): “Street views in Tokyo 2” Syced / CC0 (cropped) - Related lab (医療倫理学分野): “HippocraticOath” 作者不詳 / Public domain (cropped)
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