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Molecular Oncology Pharmacology Lab
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The lab studies blood cancers to uncover why drugs stop working and aims to develop new treatments.
AboutAbout the lab
From blood cancer to new treatments.
The Molecular Oncology Pharmacology Lab is a Social Cooperation Program of the Graduate School of Pharmaceutical Sciences, and studies hematopoietic stem cells and hematologic malignancies (blood cancers).
In basic research, the lab aims to elucidate biological phenomena; in areas closer to clinical application, it aims to study disease mechanisms, drug resistance, and combination therapies.
A distinguishing feature of the lab is that it has developed an efficient gene transfer method using retroviral vectors and uses it to advance its research.
Research is conducted through open discussion.
Key terms
- Hematologic malignancy
- Cancer, such as leukemia, that arises from cells that produce blood
- Drug resistance
- When a drug that was initially effective stops working on cancer cells and similar cells
- Immune checkpoint inhibitor
- A drug that releases the brakes cancer cells place on the immune system, allowing the immune system to attack the cancer
ResearchResearch themes
The lab aims to develop new treatments based on research on hematopoietic stem cells and hematologic malignancies. Its research topics include elucidating the mechanisms of drug resistance, combination drug therapies, treatments that activate the immune system, and the role of T cells in clonal hematopoiesis.
*Illustrative imageInvestigating how drugs stop working
Using CRISPRa (CRISPR activation), the lab grows cells with increased gene expression in the presence of a drug and examines which genes, when upregulated, make the drug less effective. By analyzing the genes it identifies, the lab clarifies the mechanisms of drug resistance and drug action.
*Illustrative imageDeveloping combination drug therapies
Based on the resistance mechanisms it has identified, the lab is considering combination therapies that pair different drugs. Its work currently uses HDAC inhibitors and DNA methylation inhibitors, and it plans to extend this to other drugs.
*Illustrative imageCancer treatment that activates the immune system
The lab focuses on the effectiveness of immune checkpoint inhibitors in cancer treatment. Using mice in which cells in the G0 phase of the cell cycle can be identified, it examines the treatment of chronic myeloid leukemia and aims to develop new treatments that activate the immune system, including drug combinations.
*Illustrative imageClonal hematopoiesis and T cells
The lab focuses on clonal hematopoiesis, in which blood cells carrying gene mutations associated with leukemia expand, and investigates whether abnormal function of T cells carrying these mutations may be a cause of disease.
MembersFaculty
The members of the Molecular Oncology Pharmacology Lab consist of faculty members, postdoctoral researchers, doctoral and master's students, and administrative assistants.As of 2024
- Professor (Concurrent)Shohei HoriPublications ↗
- Project Associate ProfessorYutaka Enomoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Acute Myeloid Leukemia (M2 type)” Makysm / CC0 (cropped)
- Investigating how drugs stop working: “CAS 4qyz” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 4.0 (cropped)
- Developing combination drug therapies: “D-L- Glucose farbig V1” Vectorization: Alhadis / Public domain (cropped)
- Cancer treatment that activates the immune system: “Chronic Myeloid Leukemia smear” Paulo Henrique Orlandi Mourao / CC BY-SA 3.0 (cropped)
- Clonal hematopoiesis and T cells: “Healthy Human T Cell” NIAID/NIH / Public domain (cropped)
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