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Yeast Fermentation Science Lab
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A lab that explores adaptation to the environment and evolution through the distinctive chromosomes of lager brewing yeast.
AboutAbout the lab
Understanding everything about brewing yeast
The lab studies the budding yeast Saccharomyces pastorianus, which is used to brew lager beer.
This yeast is an allopolyploid, meaning it carries chromosomes derived from two different yeast species.
The lab investigates, at the molecular level, the properties that arise from this distinctive chromosome structure, focusing on their relationship to stress response.
It is a social collaboration research division housed in the Collaborative Research Institute for Innovative Microbiology and operated with support from Asahi Breweries, Ltd.
Key terms
- Budding yeast
- A yeast that reproduces by forming a bulge-like bud on part of the cell. It is used in baking and brewing, and is also widely used in biological research.
- Allopolyploid
- An organism that carries multiple sets of chromosomes derived from different species. Wheat and rapeseed (Brassica napus) are well-known examples.
- Organelle
- A small structure inside a cell that has a specific function, such as mitochondria or the endoplasmic reticulum.
ResearchResearch themes
The lab studies the properties of the lager brewing yeast S. pastorianus that derive from its allopolyploid chromosomes, mainly in relation to stress response. It also aims to advance the understanding of biology related to chromosomal aneuploidy and polyploidy more broadly.
*Illustrative imageGenome instability in hybrid yeast
The lab examines genome instability in the brewing yeast S. pastorianus and in other hybrid yeasts. It is known that chromosome structure changes even while the yeast is repeatedly reused in beer production.
*Illustrative imageBehavior of organelles and proteins
The lab analyzes how organelles and proteins behave inside S. pastorianus cells.
*Illustrative imageExploring yeast characteristics with small-molecule compounds
Using small-molecule compounds, the lab analyzes the characteristics of S. pastorianus and of its ancestral yeast S. eubayanus.
*Illustrative imageGenes found only in the ancestral yeast
The lab analyzes the functions of the proteins encoded by genes found only in the genome of S. eubayanus, a yeast discovered in Patagonia, South America.
MembersFaculty
Members of the lab consist of faculty, master's and undergraduate students, and research students.
- Project Associate ProfessorYoichi NodaPublications ↗
- Associate ProfessorRyouichi FukudaPublications ↗
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Tanks at Green Leaf brewery” Ruth Hartnup from Vancouver, Canada / CC BY 2.0 (cropped)
- Genome instability in hybrid yeast: “Levaduras Aumento total 400X” BioGenZambrano / CC BY-SA 4.0 (cropped)
- Behavior of organelles and proteins: “Yeast membrane proteins” Masur / CC BY 2.5 (cropped)
- Exploring yeast characteristics with small-molecule compounds: “Yeast agar plate-01” Lilly_M / CC BY-SA 3.0 (cropped)
- Genes found only in the ancestral yeast: “Scheinbuchenwald (Nothofagus) Torres del Paine Nationalpark” Heckenmeise / CC BY-SA 4.0 (cropped)
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- Related lab (酵素学研究室): “Lysozyme crystals” Ilyassova Bayan / CC0 (cropped)
- Related lab (細胞遺伝学研究室): “Aspergillus nidulans” Plasmidmap / CC BY 3.0 (cropped)
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