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Enzymology Lab
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The lab uncovers the shape, function, and motion of enzymes from their three-dimensional structures.
AboutAbout the lab
Research on the three-dimensional structures and functions of various enzymes
The Enzymology Lab studies the three-dimensional structures and functions of various enzymes.
Enzymes are catalysts produced by living organisms, and they are used in a wide range of fields, including food, the chemical industry, medicine, and research.
Most enzymes are proteins with complex shapes, and much about how they behave remains unknown.
The lab selects enzymes of interest from both basic and applied perspectives and investigates their "shape" and "function" using methods such as X-ray crystallography.
Key terms
- X-ray crystallography
- A method of directing X-rays at crystals of proteins and other molecules to determine the arrangement of their atoms (their three-dimensional structure)
- Bifidobacteria
- A group of bacteria that live in places such as the human gut. They break down and use various oligosaccharides
- Polyketide synthase
- An enzyme that builds complex natural products by linking small building blocks together one after another
NewsLab news
A doctoral student received the Student Encouragement Award at the Quantum Beam Science Festa
A doctoral student received a Poster Award at the Cryogenic Research Center Research Exchange Meeting
Published findings on the neutron structural analysis of β-glucosidase
Published findings on the structural analysis of polyketide synthases using an ancestral design approach
Published findings on amino acid metabolism enzymes from hyperthermophiles
ResearchResearch themes
The lab selects enzymes of interest from both basic and applied perspectives and aims to clarify their "shape," "function," and "motion." Its research combines X-ray crystallography, protein engineering, and spectroscopic methods.
*Illustrative imageSugar-degrading enzymes of Bifidobacteria
The lab investigates the three-dimensional structures and functions of enzymes in Bifidobacteria that degrade oligosaccharides and glycans derived from humans and plants.
*Illustrative imageEnzymes that produce natural products
The lab investigates the three-dimensional structures and functions of enzymes that microorganisms use to produce natural products, such as polyketide synthases from actinomycetes.
*Illustrative imageDiscovery of novel carbohydrate-active enzymes
The lab searches for previously unknown enzymes involved in sugar metabolism and determines their three-dimensional structures and functions.
*Illustrative imageEnzymes that degrade plant biomass
The lab studies biomass-degrading enzymes, such as cellulases and hemicellulases from filamentous fungi and bacteria, which are used in biofuel production.
MembersFaculty
The members of the Enzymology Lab are faculty, administrative staff, postdoctoral researchers, doctoral, master's, and undergraduate students, and research students.As of 2026
- ProfessorShinya FushinobuPublications ↗
- Associate ProfessorAkimasa MiyanagaPublications ↗
- Assistant ProfessorToma KashimaPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Lysozyme crystals” Ilyassova Bayan / CC0 (cropped)
- Sugar-degrading enzymes of Bifidobacteria: “Bifidobacterium adolescentis Gram” Y tambe / CC BY-SA 3.0 (cropped)
- Enzymes that produce natural products: “Streptomyces hygroscopicus” Snuupo / CC BY-SA 4.0 (cropped)
- Discovery of novel carbohydrate-active enzymes: “6nun assembly-1” Lima, M.Z.T., Muniz, J.R.C. / CC0 (cropped)
- Enzymes that degrade plant biomass: “Cellulase 1JS4” B.T.Riley / CC BY-SA 4.0 (cropped)
- Related lab (Cellular Function Engineering Lab): “Streptomyces hygroscopicus” Snuupo / CC BY-SA 4.0 (cropped)
- Related lab (Analytical Chemistry Lab): “Nacreous aragonite ("mother-of-pearl") 1” James St. John / CC BY 2.0 (cropped)
- Related lab (Biological Function Development Chemistry Lab): “Blue tongue” Sensonet / CC BY-SA 3.0 (cropped)
- Related lab (Food Biostructure Lab): “CSIRO ScienceImage 296 Protein Crystals Use in XRay Crystallography” division, CSIRO / CC BY 3.0 (cropped)
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