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Advanced Research and Development Lab
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A lab that explores how diseases arise through the mechanisms of the genome and cells.
AboutAbout the lab
Exploring the mechanisms of disease through the genome and cells
The Research Promotion Unit of the Medical Institute of Bioregulation includes Associate Professor Takehito Uruno, Associate Professor Hiroki Shibata, and Assistant Professor Daisuke Tsuchimoto.
The linked website belongs to Associate Professor Hiroki Shibata's genomics field, which focuses on genomic diversity and phenotypes and conducts research mainly using next-generation sequencers.
Associate Professor Takehito Uruno studies signal transduction, cytoskeletal regulation, lipid metabolism, and disease control.
Assistant Professor Daisuke Tsuchimoto studies the effects of damage to DNA and free nucleotides on mammals, as well as the body's defense mechanisms.
Key terms
- Next-generation sequencer
- A device that reads DNA base sequences. A single run can yield sequence data amounting to several times the human genome
- Exome analysis
- A technique that extracts only the exons, the portions that carry gene information, and determines their base sequences all at once
- Inosine triphosphate
- One of the "non-canonical nucleotides," which differ from the usual ones. The mechanisms of its production in the body are being studied
NewsLab news
View More ↗ResearchResearch themes
In Associate Professor Hiroki Shibata's field, the aim is to understand biological phenomena from the perspectives of genetic information regulation mechanisms and molecular evolution, through the analysis of genetic diversity closely tied to disease and adaptive evolution. In the same Research Promotion Unit, Associate Professor Takehito Uruno studies signal transduction, and Assistant Professor Daisuke Tsuchimoto studies damage to DNA and free nucleotides and the body's defense mechanisms.
*Illustrative imageElucidating the Molecular Basis of Intractable Neurological Diseases
In collaboration with Ehime University, Kurume University, Kochi University, and others, the lab searches for causative mutations in familial neurological diseases collected jointly, using linkage analysis and exome analysis in combination. Targets include familial myoclonic epilepsy and familial spastic paraplegia.
*Illustrative imageGenome Analysis of the Venomous Habu Snake
The aim is to discover leads for drug discovery and to clarify how venom component genes evolve rapidly. Work includes whole-genome sequencing of the habu and its close relatives, transcriptome analysis of venom glands and other tissues, and analysis of the genetic diversity of island populations.
*Illustrative imageControlling Disease Through Signal Transduction
The lab studies signal transduction with the aim of understanding the body's responses and controlling disease. It also works on identifying new molecular targets involved in cancer, immune, and allergic diseases and applying them to drug discovery.
*Illustrative imageNon-canonical Nucleotides and Epileptic Encephalopathy
The lab studies how inosine triphosphate, one of the non-canonical nucleotides, is produced in the body, and the molecular pathology of the epileptic encephalopathy caused by its accumulation. The investigations use mice, cultured cells, and recombinant proteins.
MembersFaculty
The members of Associate Professor Hiroki Shibata's genomics field consist of faculty members, doctoral students, and collaborative researchers.As of 2026
- Associate ProfessorTakehito Uruno
- Associate ProfessorHiroki Shibata
- Assistant ProfessorDaisuke Tsuchimoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Human Genome - Chromosomes” 作者不詳 / Public domain (cropped)
- Elucidating the Molecular Basis of Intractable Neurological Diseases: “PLoSBiol4.e126.Fig6fNeuron” Wei-Chung Allen Lee, Hayden Huang, Guoping Feng, Joshua R. Sanes, Emery N. Brown, Peter T. So, Elly Nedivi / CC BY 2.5 (cropped)
- Genome Analysis of the Venomous Habu Snake: “Protobothrops flavoviridis” Airman 1st Class Hailey Staker / Public domain (cropped)
- Controlling Disease Through Signal Transduction: “Signal Transduction Model for Embryonic Differentiation Waves” Bjorklund21 / CC BY 4.0 (cropped)
- Non-canonical Nucleotides and Epileptic Encephalopathy: “EEG to measure brain current” ulrichw / CC0 (cropped)
- Related lab (Information Biology Lab): “Gene co-expression network with 7221 genes for 18 gastric cancer patients” S. Mohammad H. Oloomi / CC BY-SA 3.0 (cropped)
- Related lab (Cancer Genome Regulation Lab): “Invasive Breast Cancer in 3D” Sshah74 / CC BY 4.0 (cropped)
- Related lab (Biomedical Information Analysis Lab): “Geographical distribution of human major genetic ancestral components” Wikiuser1314 / CC BY-SA 4.0 (cropped)
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