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トランススケール構造生命科学
Showing the original Japanese · View translation
タンパク質の品質管理の仕組みを構造から細胞まで探る研究室。
AboutAbout the lab
構造と細胞の両面から、タンパク質の品質管理を解く。
トランススケール構造生命科学分野は、
タンパク質は
この
研究室の
Key terms
- 小胞体
- 細胞内小器官の
一つ。 分泌タンパク質や膜タンパク質が 合成される 区画 - ジスルフィド結合
- システイン2つの
間に できる 硫黄どうしの 結合。 タンパク質の 立体構造を 安定させる - 小胞体関連分解
- 正しく
折りたたまれなかった タンパク質を 細胞質へ 送り返し、 分解する 仕組み - ERp44
- ゴルジ体で、
小胞体に 戻すべきタンパク質を 捕まえて 送り返すタンパク質
NewsLab news
生医研リトリートで、
学生が 優秀講演賞と 最優秀ポスター賞を 受賞 ERp44と
ERGIC-53の 総説が、 Journal of Biochemistry 誌に 掲載 SERCA2と
SPCA1の 比較に 関する 総説が、 Biochemical Journal 誌に 掲載 天貝助教らが、
小胞体での 亜鉛と レドックスの 関係を 発見し、 Nature Communications 誌に 論文が 掲載
ResearchResearch themes
この
*Illustrative image小胞体のジスルフィド結合の仕組み
哺
*Illustrative image不良品タンパク質を分解する仕組み
小胞体の
*Illustrative imageゴルジ体から小胞体への回収の仕組み
ERp44は、
*Illustrative image金属イオンの濃度を保つ仕組み
多くの
MembersFaculty
トランススケール構造生命科学分野の
- Senior Professor稲葉 謙次
- Associate Professor渡部 聡
- Assistant Professor天貝 佑太
- Assistant Professor藤井 唱平
- Project Associate Professor門倉 広
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “XBio illustration – Endoplasmic Reticulum” explorebiology / CC BY 4.0 (cropped)
- 小胞体の
ジスルフィド結合の 仕組み: “C17orf58 protein (UPF0450) structure with AlphaFold” Luyu9927 / CC BY 4.0 (cropped) - 不良品タンパク質を
分解する 仕組み: “Ubiquitin cartoon” en:User:Rogerdodd / Public domain (cropped) - ゴルジ体から
小胞体への 回収の 仕組み: “Golgi apparatus 2 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped) - 金属イオンの
濃度を 保つ 仕組み: “Zinc (Element - 30)” James St. John / CC BY 2.0 (cropped) - Related lab (ネットワークAI統計解析部門): “Airports Network Map” Martin Grandjean / CC BY-SA 4.0 (cropped)
- Related lab (細胞不均一性学): “Skeletal Muscle Tissue” Community College Bioscience / CC0 (cropped)
- Related lab (疾患ゲノム生物学): “Histological section of small intestine epithelial tissue, zoom” Otávio Astor Vaz Costa / CC BY 4.0 (cropped)
- Related lab (トランスクリプトミクス): “Chromatin Structures” Original uploader was Richard Wheeler at en.wikipedia / CC BY-SA 3.0 (cropped)
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