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Oral and Maxillofacial Surgery Lab
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A lab that treats diseases of the mouth, jaw, and face while also investigating mechanisms of immunity and tumors.
AboutAbout the lab
Aiming for a department where young members enjoy their work and find it rewarding.
The Oral and Maxillofacial Surgery Lab is part of the Faculty of Dental Science at Kyushu University, and also provides clinical care as the Maxillofacial and Oral Surgery department of Kyushu University Hospital.
Its main clinical areas are maxillofacial shape abnormalities such as jaw deformities and cleft lip and palate, temporomandibular joint diseases, and reconstruction using implants and regenerative techniques.
Its research examines salivary gland diseases such as Sjögren's syndrome and IgG4-related disease, osteomyelitis of the jaw, and metastasis of oral cancer.
Aiming to be a department where young members enjoy their work and find it rewarding, the lab also works to train people who will support the next generation of dental care.
Key terms
- IgG4-related disease
- A disease with high blood IgG4 levels and tissue fibrosis in many organs. The concept was proposed in Japan.
- Sjögren's syndrome
- An autoimmune disease that damages organs such as the salivary and lacrimal glands.
- Myristoylation
- A post-translational modification of proteins, considered important for immune responses.
- Single cell
- Examining cells one at a time. This is distinguished from methods that analyze a whole tissue together.
NewsLab news
A student won the Poster Award at the 50th Annual Meeting of the Japanese Cleft Palate Association.
A student won the Congress President's Award at the 35th Annual Meeting of the Japanese Society of Oral Medicine and the 38th Annual Meeting of the Japan Society of Oral Diagnosis.
A student won the Young Investigator Excellence Poster Award at the 79th Annual Meeting of the Japanese Stomatological Society.
Assistant Professor Naoki Kaneko won a Poster Award at the Korean Association of Oral and Maxillofacial Surgeons meeting.
Assistant Professor Naoki Kaneko received the Young Scientists' Award in the Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology (FY2025).
ResearchResearch themes
While providing care for conditions such as jaw deformities and cleft lip and palate, the lab conducts basic research on salivary gland diseases, osteomyelitis of the jaw, and oral cancer, as well as clinical research on jaw deformities. The lab's website states that each member pursues diverse research in the area that interests them.
*Illustrative imagePathology of IgG4-Related Disease and Model Mice
The lab examines salivary gland lesions of IgG4-related disease using multiplex fluorescence staining and single-cell analysis, to find molecules involved in innate immunity that are specific to the disease. It aims to establish model mice through gene transfer and to develop new treatments.
*Illustrative imageAutoantibodies and Pathology of Sjögren's Syndrome
Sjögren's syndrome is an autoimmune disease that damages the salivary and lacrimal glands. The lab focuses on tissue-specific autoantigens directly involved in its onset. It aims to identify disease-specific autoantigens, apply them to diagnosis, and establish new treatments.
*Illustrative imageOsteomyelitis of the Jaw and Osteoimmunology
The causes and mechanisms of osteomyelitis of the jaw are largely unclear, and no established treatment exists. Focusing on osteoblasts, the lab studies the relationship between inflammatory responses and protein myristoylation.
*Illustrative imageMechanisms of Oral Cancer Metastasis
The lab establishes cell lines from the primary oral cancer tumor and from a lymph node metastasis that appeared later in the same patient, and examines differences in their properties. It is also conducting research that recreates the early stage of metastasis by co-culturing single cells isolated from the primary tumor with lymphocytes from the same patient.
MembersFaculty
The members of the Oral and Maxillofacial Surgery Lab are Professors, Lecturers, Assistant Professors, clinical staff, research fellows, and graduate students, and some members are currently on assignment at affiliated hospitals and other institutions.
- ProfessorMasafumi Moriyama
- LecturerWataru Kumamaru
- LecturerYukiko Ohyama
- Assistant ProfessorGoro Sugiyama
- Assistant ProfessorAyako Kozuma
- Assistant ProfessorNaoya Yoshihama
- Assistant ProfessorMinami Shibuya
- Assistant ProfessorTomoko Kizuki
- Assistant ProfessorNaoki Kaneko
- Assistant ProfessorSosuke Takahata
- Assistant ProfessorHu Chen
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Oral surgery clinic saves patients time and money 160316-F-AR942-002” Airman 1st Class Kaylee Dubois / Public domain (cropped)
- Pathology of IgG4-Related Disease and Model Mice: “Low power view of IgG4-related prostatitis” © María T. Bourlon, Mónica Sánchez-Ávila, Fredy Chablé-Montero, Ricardo Arceo-OlaizMaría T. Bourlon, Mónica Sánchez-Ávila, Fredy Chablé-Montero, and Ricardo Arceo-Olaiz / CC BY 3.0 (cropped)
- Autoantibodies and Pathology of Sjögren's Syndrome: “Sjogren's syndrome 1” No machine-readable author provided. KGH assumed (based on copyright claims). / CC BY-SA 3.0 (cropped)
- Osteomyelitis of the Jaw and Osteoimmunology: “Basic panoramic radiograph” w: Coronation Dental Specialty Group / CC BY 3.0 (cropped)
- Mechanisms of Oral Cancer Metastasis: “Sinonasal metastasis of intestinal cancer CTI 035” Jmarchn / CC0 (cropped)
- Related lab (Maxillofacial Tumor Control Lab): “Cleft palate alveolus panorex xray” Coronation Dental Specialty Group / CC BY-SA 4.0 (cropped)
- Related lab (Implant and Denture Prosthodontics Lab): “Prettau Bridge - (TLZ-IB)” Roedentallab / CC BY-SA 3.0 (cropped)
- Related lab (Advanced Dental Care Evaluation and Development Lab): “Warwick james dental elevators” Sadandy / CC BY-SA 4.0 (cropped)
- Related lab (Oral Cell Engineering Lab): “Bone degrading cells - Osteoclasts 3 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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