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Oral Cell Engineering Lab
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The lab investigates how information is transmitted inside cells, starting from the molecular level.
AboutAbout the lab
Studying intracellular signaling at the molecular level
The Oral Cell Engineering Lab is part of the Department of Normal Oral Function Regulation in the Faculty of Dental Science at Kyushu University, and it studies how information is transmitted inside cells.
Its predecessor was the Department of Oral Biochemistry, established in 1968, which took its current name in the organizational restructuring of 2000.
The lab has examined from many angles the physiological functions of a protein that binds inositol 1,4,5-trisphosphate, which it discovered in 1992.
Its current research themes also include the regulation of bone metabolism by the transcription factor NF-κB.
Key terms
- NF-κB
- A transcription factor that regulates the expression of genes involved in inflammation and immune responses.
- Osteoclasts
- Cells that resorb bone. It has been reported that when estrogen is deficient, bone resorption is enhanced through NF-κB.
ResearchResearch themes
The Oral Cell Engineering Lab studies how information is transmitted inside cells, using cell biology and molecular biology experiments. Its research covers functional analysis of proteins that bind inositol 1,4,5-trisphosphate, and the regulation of bone and metabolism by NF-κB.
*Illustrative imageProteins Responsible for Intracellular Signaling
Using cell biology and molecular biology experiments, the lab studies the roles that inositol phosphates and inositol phospholipids play in intracellular signaling, focusing mainly on functional analysis of proteins that bind inositol 1,4,5-trisphosphate.
*Illustrative imageNF-κB and the Regulation of Bone Metabolism
The lab investigates the molecular basis of how the transcription factor NF-κB regulates bone metabolism, focusing on bone metabolism and osteoclasts. It aims to use the findings to develop new therapeutic strategies.
*Illustrative imagePostmenopausal Bone Loss and Weight Gain
The lab studies the relationship between NF-κB activation under estrogen deficiency and bone loss and weight gain. A published paper has shown that in ovariectomized mice, NF-κB is activated in the metaphysis of long bones and in white adipose tissue.
*Illustrative imageOral Cancer Progression and p65 Modification
Focusing on deamidation of p65, a transcription factor that is part of NF-κB, the lab studies the mechanisms by which oral squamous cell carcinoma progresses.
MembersFaculty
- ProfessorEijiro Jimi
- LecturerYoshikazu Hayashi
- Assistant ProfessorJing Gao
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Bone degrading cells - Osteoclasts 3 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Proteins Responsible for Intracellular Signaling: “PBB Protein NF1 image” The original uploader was ProteinBoxBot at English Wikipedia. / Public domain (cropped)
- NF-κB and the Regulation of Bone Metabolism: “Bone degrading cells - Osteoclast precursors -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Postmenopausal Bone Loss and Weight Gain: “Menopause - Osteoporosis -- Smart-Servier (cropped)” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Oral Cancer Progression and p65 Modification: “Fluorescence microscopy of the DNA of the oral cancer cells” Korinna / CC BY 4.0 (cropped)
- Related lab (歯科保存学分野): “Pulp tissue removed during endodontic therapy by a size 20 broach file” DRosenbach at en.Wikipedia / Public domain (cropped)
- Related lab (口腔機能解析学分野): “1402 The Tongue” OpenStax / CC BY 4.0 (cropped)
- Related lab (口腔顎顔面外科学分野): “Oral surgery clinic saves patients time and money 160316-F-AR942-002” Airman 1st Class Kaylee Dubois / Public domain (cropped)
- Related lab (歯科麻酔学分野): “Local Dental Anesthesia Preparation” Jameswasswa / CC BY-SA 4.0 (cropped)
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