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Periodontology Lab
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The lab investigates the relationship between periodontal disease and the whole body at the molecular level.
AboutAbout the lab
Uncovering the link between periodontal disease and the whole body at the molecular level.
The lab studies the relationship between periodontal disease and systemic conditions, including diabetes, in terms of molecular mechanisms.
Using mice, the lab examines how obesity and diabetes affect periodontitis and how periodontitis affects the whole body.
The lab also studies how amelogenin, which is used as a material for regenerating periodontal tissue, acts on the immune system.
The lab belongs to the Department of Oral Rehabilitation at the Faculty of Dental Science, Kyushu University, and some of its faculty members also provide clinical care at the Periodontology Clinic of Kyushu University Hospital.
Key terms
- Periodontal disease
- A disease affecting the periodontal tissues that support the teeth, such as the gums and bone. Its relationship with diabetes is being studied
- Insulin resistance
- A condition in which insulin, the hormone that lowers blood glucose, does not work as effectively
- Amelogenin
- A protein used as a material for regenerating periodontal tissue. Its ability to suppress immune responses is being studied
NewsLab news
A doctoral student received the Hiroshi Fujino Award at the degree conferment ceremony of the Graduate School of Dental Science
A doctoral student received the Poster Award (1st Place) at the 2025 KAP Scientific Meeting
Assistant Professor Takanori Shinjo received the FY2025 Academic Award of the Japanese Society of Periodontology
A doctoral student received the Excellence Award for an interim presentation
ResearchResearch themes
Using mice, the lab investigates at the molecular level how periodontal disease and systemic conditions such as diabetes and obesity influence each other. It also works on developing new methods to promote healing of diabetes-related periodontitis.
*Illustrative imageRelationship between diabetes/obesity and periodontitis
Through basic research, the lab examines how periodontal disease affects systemic diseases such as diabetes and general health, and how obesity and diabetes affect the pathology of periodontitis.
*Illustrative imageChanges in adipose tissue immunity caused by periodontitis
The lab examines how the immunity of visceral adipose tissue changes in response to periodontitis. It also studies in mice the mechanisms by which inflammation of adipose tissue worsens periodontitis.
*Illustrative imagePromoting healing of diabetes-related periodontitis
This research uses insulin sensitizers to develop a new method for promoting healing of diabetes-related periodontitis. It focuses on insulin resistance in vascular endothelial cells.
*Illustrative imageAmelogenin and immunity
The lab examines how amelogenin, which is used as a material for regenerating periodontal tissue, suppresses immune responses. It has reported that amelogenin prolongs graft survival in mouse skin transplantation.
MembersFaculty
The members of the Periodontology Lab consist of a Professor Emeritus, a Lecturer, Assistant Professors, clinical staff, postgraduate residents, doctoral students, research fellows, and registered trainee dentists.As of 2025
- LecturerTerukazu Sanui
- LecturerTakao Fukuda
- Assistant ProfessorAkiko Yamashita
- Assistant ProfessorTakanori Shinjo
- Assistant ProfessorChikako Hayashi
- Assistant ProfessorTatsuro Zeze
- Assistant ProfessorMiyu Shida
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Depiction of a Periodontitis patient” https://www.myupchar.com/en / CC BY-SA 4.0 (cropped)
- Relationship between diabetes/obesity and periodontitis: “Glucose test” Erik1980 / CC BY-SA 3.0 (cropped)
- Changes in adipose tissue immunity caused by periodontitis: “Adipose tissue” Yuki T. Okamura / CC0 (cropped)
- Promoting healing of diabetes-related periodontitis: “Full automatic Dental Chair in Kar Clinic” AuliRaha / CC BY-SA 4.0 (cropped)
- Amelogenin and immunity: “My Public Lands Roadtrip- Rimrock Draw Rockshelter in Oregon ( )” Bureau of Land Management / Public domain (cropped)
- Related lab (Oral Function Analysis Lab): “1402 The Tongue” OpenStax / CC BY 4.0 (cropped)
- Related lab (Oral Pathology Lab): “1963. Fundamental research on pathogenic micro-organisms is aided by the use of the electron microscope. Corvallis, Oregon. ( )” R6, State & Private Forestry, Forest Health Protection / Public domain (cropped)
- Related lab (Oral and Brain Function Pathology Lab): “Toothbrush, Toothpaste, Dental Care (571741)” Steve Buissinne, South Africa / CC0 (cropped)
- Related lab (Oral Preventive Medicine Lab): “Toothbrush x” Jonas Bergsten / Public domain (cropped)
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