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Molecular Oral Anatomy Lab
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The lab studies mesenchymal stem cells in the oral cavity and the mechanisms that regulate bone metabolism.
AboutAbout the lab
Exploring oral stem cells and bone metabolism
The Molecular Oral Anatomy Lab studies mesenchymal stem cells in the oral cavity and the mechanisms that regulate bone metabolism.
At the undergraduate level, the lab teaches oral anatomy, tooth anatomy, oral histology, and oral embryology, as well as systemic anatomy, histology, and embryology.
At the graduate level, students study a wide range of phenomena at the tissue, cellular, and molecular levels through research grounded in molecular biology. The lab aims to train researchers and dentists with a deep understanding of basic medicine and life sciences.
Key terms
- Mesenchymal stem cells
- Stem cells with multipotency and immunosuppressive effects. They are also found in various oral tissues.
- Osteoclasts
- Cells involved in bone destruction. The mechanisms of their differentiation and activation are being studied in conditions such as inflammation-associated bone destruction.
ResearchResearch themes
The lab uses mesenchymal stem cells from oral tissues to study disease pathology, and it also studies the mechanisms of bone destruction. It conducts research and development on advanced medicine using stem cells, and develops new methods that stop only pathological bone destruction.
*Illustrative imageResearch on Oral Mesenchymal Stem Cells
Mesenchymal stem cells are expected to be applied in regenerative medicine. The lab uses these stem cells, which are found in various oral tissues, to investigate how the pathology of a range of diseases is regulated. It also conducts an observational study of the pathology of Dravet syndrome using stem cells from deciduous teeth.
*Illustrative imageRegulation of Bone Metabolism
The lab studies the molecular mechanisms by which osteoclasts differentiate and become activated in bone destruction associated with inflammation, such as periodontal disease and arthritis, and in bone metastasis of cancer. It is developing new methods that stop only pathological bone destruction while preserving normal bone remodeling.
MembersFaculty
The members of the Molecular Oral Anatomy Lab consist of faculty members, educational support staff, graduate students, research students, and secretaries.
- ProfessorTakayoshi Yamaza
- Assistant ProfessorNorihisa Uehara
- Assistant ProfessorHiroki Kato
- Assistant ProfessorYukari Kyumoto
- Assistant ProfessorSoichiro Sonoda
- Assistant ProfessorZAKARIA MHD FOUAD
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Bone degrading cells - Osteoclast precursors 2 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Research on Oral Mesenchymal Stem Cells: “Whartons-jelly-mesenchymal-stem-cells” [<a href="https://www.amaskincare.com/about/alice-pien-md-medical-director/">Alice Pien, MD</a>] / CC BY-SA 4.0 (cropped)
- Regulation of Bone Metabolism: “Bone regeneration - Bone remodeling cycle I - Endosteal Sinus Monocyte Pre-osteoclast etc -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Pediatric Oral Medicine Lab): “Pediatric Dentistry Residents with pre-doctoral students at Give Kids a Smile 2014” Brendan John / CC BY 3.0 (cropped)
- Related lab (Oral Pathology Lab): “1963. Fundamental research on pathogenic micro-organisms is aided by the use of the electron microscope. Corvallis, Oregon. ( )” R6, State & Private Forestry, Forest Health Protection / Public domain (cropped)
- Related lab (Dental Development and Regeneration (DDR) Lab): “Tooth Extraction in Action- The 86th Dental Squadron (9478736)” U.S. Air Force photo by Airman Paden Henry / Public domain (cropped)
- Related lab (Oral Functional Molecular Science Lab): “Oral cancer (1) squamous cell carcinoma histopathology” No machine-readable author provided. KGH assumed (based on copyright claims). / CC BY-SA 3.0 (cropped)
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