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Biological Function Analysis Lab
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This research unit works on basic research on mitochondria and on developing new measurement methods in clinical chemistry.

AboutAbout the lab
Exploring cell function and laboratory testing through mitochondria
The Biological Function Analysis Lab is a research unit that conducts basic research on mitochondria and develops new measurement methods in clinical chemistry.
Mitochondrial DNA encodes subunits of the electron transport chain that synthesizes ATP, and is considered an essential genome for cells to maintain normal function.
The lab investigates the functions of genes involved in the replication, transcription, and translation of mitochondrial DNA, as well as the function of the mitochondrial protein p32.
Key terms
- Mitochondrial DNA
- The unique DNA that mitochondria possess. It encodes subunits of the electron transport chain that synthesizes ATP.
- Electron transport chain
- The system inside mitochondria that is involved in synthesizing ATP.
- p32
- A protein in the mitochondrial matrix.
- Mitochondrial encephalomyopathy
- A hereditary disease caused by mutations in mitochondrial genes. MELAS is one example.
ResearchResearch themes
This research unit works on building the foundations of clinical chemistry and developing new measurement methods, and also studies mitochondria as basic research. In its analysis of the mitochondrial protein p32, the lab aims to examine how mitochondria affect cells and whole organisms, from the organism level down to the molecular level.
*Illustrative imageDeveloping measurement methods for clinical chemistry
The lab works on building the foundations of clinical chemistry and developing new measurement methods. Recently, it reported a highly sensitive method for measuring serum creatinine using an enzymatic cycling reaction.
*Illustrative imageFunctions of the mitochondrial protein p32
The lab analyzes the function of p32, a protein in the mitochondrial matrix, from the organism level to the molecular level. It aims to elucidate new molecular mechanisms inferred from the analysis of tissue-specific knockout mice.
*Illustrative imageLinks between mitochondria and lysosomes
The lab investigates how mitochondrial and lysosomal functions are connected, with keywords such as NAD. It aims to elucidate new molecular mechanisms.
*Illustrative imageGenetic mutations in mitochondrial disease
MELAS, a mitochondrial encephalomyopathy, is a hereditary disease in which the A>G mutation at position 3243 of a mitochondrial tRNA gene is frequently reported. The lab studies the function of a single nucleotide polymorphism at position 3290 that suppresses the effect of this mutation.
MembersFaculty
- ProfessorTakeshi Uchiumi
- Associate ProfessorEisaku Hokazono
- Assistant ProfessorSaori Ueda
- Assistant ProfessorMikako Yagi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “2026 - Blood test samples” Oleg Yunakov / CC BY-SA 4.0 (cropped)
- Developing measurement methods for clinical chemistry: “Clinical Chemistry Analyzer , Клинички биохемиски анализатор 3” Делфина / CC BY-SA 4.0 (cropped)
- Functions of the mitochondrial protein p32: “Mitochondria, mammalian lung - TEM” Louisa Howard / Public domain (cropped)
- Links between mitochondria and lysosomes: “Mitokondrid, mikrofilamendid ja tuumad rakkudes” Heiti Paves / CC BY-SA 3.0 (cropped)
- Genetic mutations in mitochondrial disease: “Mitochondrial DNA lg” National Human Genome Research Institute / Public domain (cropped)
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- Related lab (Pathophysiological Information Analysis Lab): “Warm Autoimmune Hemolytic Anemia ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Related lab (Pathophysiological Function Analysis Lab): “Numerous serological tests based on immunochromatography in Clinical Microbiology after assaying” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
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