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Basic Stem Cell Biology Lab
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The lab investigates how neural stem cells differentiate, with the aim of regenerating nerves.
AboutAbout the lab
Decoding neural stem cells to advance regeneration
The lab studies how neurons and glial cells, which make up the brain and nervous system, are produced from common neural stem cells.
The differentiation of neural stem cells is controlled not only by extracellular factors but also by intracellular mechanisms known as epigenetics, including DNA methylation.
The lab aims to uncover how this differentiation is controlled and to apply the resulting findings to the repair and regeneration of damaged nerve function.
Lab visits and tours are accepted at any time.
Key terms
- Epigenetics
- Changes inside the cell that affect gene function, such as DNA methylation and histone modification
- Glial cells
- Major cells that make up the brain and nervous system, produced from neural stem cells together with neurons
- Direct reprogramming
- A technology that converts cells that are not neurons directly into neurons, without going through iPS cells or similar intermediates
NewsLab news
A student received the Junior Investigator Poster Award at the 48th Annual Meeting of the Japan Neuroscience Society
Prof. Nakashima received the Prize for Science and Technology (Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology)
A lab member received an Excellent Presentation Award at the 18th Neural Development Discussion Meeting
A paper from the lab was selected for the cover of Epigenomes
A lecturer received an Excellent Oral Presentation Award at the results meeting of the Advanced Animal Model Support Platform
ResearchResearch themes
The lab investigates how neural stem cells branch into neurons and glial cells, looking at both intracellular mechanisms such as epigenetics and extracellular factors. It aims to apply the resulting findings to the repair and regeneration of damaged nerve function.
*Illustrative imageEpigenetic Control of Differentiation
The lab analyzes changes in DNA methylation and histone modification as neural stem cells become committed to each cell lineage, and investigates how these changes work together with extracellular factors to control lineages. It also aims to manipulate epigenetic regulation with non-coding RNAs and convert cells into highly useful cell types.
*Illustrative imageControlling Neural Differentiation from Pluripotent Stem Cells
ES cells and iPS cells are pluripotent stem cells that can differentiate into every cell type in the body. The lab aims to clarify the mechanisms that control their differentiation into neural cells.
*Illustrative imageNerve Repair by Direct Reprogramming
The lab transplants neural stem cells that efficiently produce neurons into mouse models of nerve injury and other models, and evaluates the improvement in the repair of nerve function. It also aims to develop technology that converts microglia and astrocytes directly into neurons, and to establish treatments for spinal cord injury and cerebral infarction.
*Illustrative imageRegulation of Adult Neural Stem Cells and Medical Applications
Neural stem cells also exist in the adult brain, and newly generated neurons have been shown to contribute to memory and learning in the hippocampus. It has also become clear that abnormalities in this process are closely linked to neurological disease. The lab aims to clarify the mechanisms that regulate the behavior of adult neural stem cells during aging and neurological disease, and to apply them to treatment.
MembersFaculty
The members of the Basic Stem Cell Biology Lab are faculty, project assistant professors, doctoral, master's, and undergraduate students, technical assistants, and secretaries.As of 2025
- Professor (Senior Chief Professor)Kinichi Nakashima
- Assistant ProfessorHideyuki Nakashima
- Assistant ProfessorTaichi Umeyama
- Assistant ProfessorKentaro Baba
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Neural Stem Cells and Growth Hormone Receptor” Pdevesap / CC BY-SA 4.0 (cropped)
- Epigenetic Control of Differentiation: “Epigenetics modifications” Jean141 / CC BY-SA 4.0 (cropped)
- Controlling Neural Differentiation from Pluripotent Stem Cells: “Vj5” David Gamm / CC BY-SA 4.0 (cropped)
- Nerve Repair by Direct Reprogramming: “Example of a neuron” BrunelloN / CC BY-SA 4.0 (cropped)
- Regulation of Adult Neural Stem Cells and Medical Applications: “Hippocampus - DK ATLAS” RAZVAN V. MARINESCU / CC BY 4.0 (cropped)
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- Related lab (Neuropsychiatry Lab): “Rat primary cortical neuron culture, 3D reconstruction ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
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