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Animal Reproductive Physiology Lab
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A lab that explores the beginning of life in mammals at the molecular level.
AboutAbout the lab
Exploring the "beginning of life" at the molecular level.
The Animal Reproductive Physiology Lab studies the process of the "beginning of life" in mammals.
It investigates the genes that are important from oocyte maturation, fertilization, and early development through implantation and placenta formation, as well as their mechanisms of action.
So far, the lab has obtained findings such as the discovery of a new nuclear structure in the fertilized egg.
By clarifying the mechanisms that control reproduction, the lab pursues research that leads to the development of new reproductive technologies.
Key terms
- Reprogramming
- The process of returning the nucleus of a differentiated cell to an undifferentiated state.
- Nuclear actin
- Actin, a protein, that is present inside the cell nucleus.
- Three-dimensional culture
- A method of culturing cells in three dimensions. It has been shown to give cells properties closer to those in the body than monolayer culture does.
NewsLab news
An Assistant Professor received the Journal of Reproduction and Development Outstanding Paper Award at the 119th Annual Meeting of the Japanese Society of Reproduction and Development
A doctoral student received an Excellent Presentation Award at the 134th Annual Meeting of the Japanese Society of Animal Science
ResearchResearch themes
This lab studies the genes that are important from oocyte maturation, fertilization, and early development through implantation and placenta formation in mammals, as well as their mechanisms of action. By elucidating the intracellular phenomena that underlie embryonic development, the lab works on key issues in animal reproductive physiology.
*Illustrative imageUnderstanding the Beginning of Life through Nuclear Structure
The lab studies how the sperm and oocyte genomes are converted into the configuration of the early embryo as the fertilized egg forms. Focusing on the nucleoskeleton, including nuclear actin and lamin proteins, it aims to elucidate the mechanisms that control embryonic development.
*Illustrative imageArtificial Control of Reprogramming
The process of returning the nucleus of a differentiated cell to an undifferentiated state is called reprogramming. The lab seeks to understand reprogramming well enough to control it artificially and apply it, with expected applications including the efficient production of cloned animals and genome analysis of cells from animals that are extinct in the wild.
*Illustrative imageDeveloping Technology to Predict Embryo Quality
In animal breeding and assisted reproductive technology, accurately selecting high-quality embryos has become an urgent problem. Based on knowledge of the molecules related to embryo quality, the lab develops a new method for selecting high-quality embryos at the molecular level, aiming to provide new technologies for livestock breeding and assisted reproductive technology.
*Illustrative imageThree-Dimensional Culture of Endometrial Cells
Cells grown in three-dimensional culture have been shown to be closer to cells in the body, in both morphology and physiology, than cells grown in ordinary monolayer culture. The lab has established various three-dimensional culture methods and is using them to analyze the function of the endometrium.
MembersFaculty
The members of the Animal Reproductive Physiology Lab consist of faculty, academic researchers, administrative assistants, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorKei Miyamoto
- Associate ProfessorNobuhiko Yamauchi
- Assistant ProfessorShiori Ashibe
- Assistant ProfessorTakuto Yamamoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Deer embryos” Tiia Monto / CC BY-SA 3.0 (cropped)
- Understanding the Beginning of Life through Nuclear Structure: “3D-SIM-2 Nucleus prophase 3d rotated” Lothar Schermelleh / CC BY-SA 3.0 (cropped)
- Artificial Control of Reprogramming: “CSIRO ScienceImage 1521 iPS cells in the lab” , CSIRO / CC BY 3.0 (cropped)
- Developing Technology to Predict Embryo Quality: “Blastocyst, day 5” Ekem at English Wikipedia / Public domain (cropped)
- Three-Dimensional Culture of Endometrial Cells: “Cystic Hyperplasia of Endometrium 10x” Calicut Medical College / CC BY-SA 4.0 (cropped)
- Related lab (Horticultural Science Lab): “Fruit Orchard - geograph.org.uk - 2349156” Oast House Archive / CC BY-SA 2.0 (cropped)
- Related lab (Fermentation Chemistry Lab): “Yeast cells in Gram stain” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (Zoology Lab): “IVF laboratory” Galina Fomina / CC BY 4.0 (cropped)
- Related lab (Gene Regulation Lab): “Genome Sequencer2” Database Center for Life Science (DBCLS) / CC BY 3.0 (cropped)
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