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Marine Resource Chemistry Lab
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The lab investigates lipid metabolism in marine microbes and pathogens through the enzymes involved.
AboutAbout the lab
Reading the lipids of marine microbes through enzymes
The Marine Resource Chemistry Lab studies the structure and function of enzymes that synthesize and degrade lipids such as glycolipids and sphingolipids.
Using labyrinthulids (Labyrinthulomycetes), microbes that live in the sea, as subjects, the lab investigates the whole picture of lipid metabolism.
The lab also works on elucidating the infection mechanisms of pathogenic bacteria, and on developing new antifungal drugs that target glycolipid metabolism in pathogenic fungi.
Key terms
- Labyrinthulomycetes
- Single-celled microbes that live in the sea. They have no chloroplasts and take in marine organic matter by decomposing it
- Sphingolipids
- Complex lipids containing a sphingosine base. Those with attached sugars are called glycosphingolipids
- Polyunsaturated fatty acids (PUFA)
- A group of fatty acids that includes DHA. Labyrinthulomycetes can accumulate large amounts of them inside their cells
NewsLab news
Paper on changing the fatty acid composition of labyrinthulids by genome editing published in Chemical Engineering Journal
Prof. Nozomu won the 8th JSC Award of the Ceramide Research Society
Paper on the degradation of lipid droplets in labyrinthulids published in Marine Biotechnology
Assistant Professor Ishibashi won the Topics Award at the 2025 Annual Meeting of the Japan Society for Bioscience, Biotechnology, and Agrochemistry
Paper on the polyunsaturated fatty acid synthesis ability of cultured fish cells published in Fisheries Science
ResearchResearch themes
The lab aims to elucidate the structure and biological function of enzymes involved in glycolipid and lipid metabolism. Recently, based on draft genome analysis of labyrinthulids, it has also focused on elucidating the whole picture of lipid metabolism and on obtaining mutant strains with altered metabolism.
*Illustrative imageElucidating lipid metabolism in labyrinthulids
In labyrinthulids, the lab investigates the development of genetic engineering techniques, the synthesis and degradation of polyunsaturated fatty acids, the synthesis and degradation of various lipids, and the mechanisms of lipid droplet formation and maintenance.
*Illustrative imageEnzymes of glycolipids and sphingolipids
The lab investigates the structure and function of enzymes involved in glycolipid and sphingolipid metabolism, including endoglycoceramidase and related enzymes, glycolipid synthases, ceramidases, and ceramide N-deacylase.
*Illustrative imageInfectious disease and the role of glycolipids
The lab investigates the expression and pathogenicity of ceramidase in Pseudomonas aeruginosa, and glycolipid metabolism in pathogenic fungi as a target for new antifungal drugs.
MembersFaculty
The members of the Marine Resource Chemistry Lab consist of faculty, administrative staff, academic collaborators, doctoral, master's, and bachelor's students, and research students.As of 2026
- ProfessorNozomu Nozomu
- Assistant ProfessorYohei Ishibashi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Seawater and rocks” Deishini Mariam / CC BY-SA 4.0 (cropped)
- Elucidating lipid metabolism in labyrinthulids: “Phycophthorum isakeiti LM-A” Brandon T. Hasset / CC BY 4.0 (cropped)
- Enzymes of glycolipids and sphingolipids: “Glycolipide” Cvf-ps / Public domain (cropped)
- Infectious disease and the role of glycolipids: “Neutrophils with intracellular bacteria on peripheral blood smear” Spicy / CC BY-SA 4.0 (cropped)
- Related lab (Microbial Technology Lab): “Joghurt” No machine-readable author provided. Rainer Zenz assumed (based on copyright claims). / CC BY-SA 3.0 (cropped)
- Related lab (Forest Chemistry Lab): “Conifer resin from Agathis lanceolata (New Caledonia, southwestern Pacific Basin) )” James St. John / CC BY 2.0 (cropped)
- Related lab (Microbial Genetic Resources Lab): “Aerial image of Grand Prismatic Spring (view from the south)” Carsten Steger / CC BY-SA 4.0 (cropped)
- Related lab (Agrochemical Chemistry Lab): “Schlenk flask 500mL” Ichwarsnur / CC BY-SA 4.0 (cropped)
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