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Aquatic Biochemistry Lab
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The lab investigates the immune mechanisms of fishes at the molecular and cellular levels.
AboutAbout the lab
Unraveling fish immunity from molecules and cells
The Aquatic Biochemistry Lab studies the mechanisms of innate and adaptive immunity in aquatic organisms, mainly fishes, at the molecular and cellular levels.
As damage from infectious diseases in farmed fish becomes serious, the lab's goal is to develop preventive methods that use the immunity fish naturally possess.
The lab focuses on fully elucidating the fish complement system, aiming to approach the whole picture of innate immunity in teleosts.
How vaccines and immune-enhancing substances work is also a subject of study.
Key terms
- Innate immunity
- An immune mechanism that is present from birth and quickly attacks and prevents pathogens
- Adaptive immunity
- An immune mechanism that remembers a pathogen it has encountered once and prepares for the next encounter
- Complement system
- An immune mechanism in which proteins in the blood work in a chain to help eliminate pathogens
- Affinity silk
- Silk protein linked to part of an antibody. The lab is studying it as a tool to prevent fish diseases
ResearchResearch themes
To contribute to the healthy rearing of aquatic organisms, the lab investigates the mechanisms of innate and adaptive immunity, mainly in fishes, using molecular and cell biology methods. How vaccines and immune-enhancing substances work is also a subject of study.
*Illustrative imageDiversification of the complement system in fishes
In fishes, the genes for complement components are highly multiplied and their functions are diverse. The lab investigates the genetic mechanisms of this diversification and how the functions of each component have diverged, aiming to approach the whole picture of innate immunity in teleosts.
*Illustrative imageAdaptive immunity and cell-mediated immunity in fish
Associate Professor Somamoto used clonal ginbuna crucian carp and their cell lines to show that fish leukocytes have capabilities comparable to mammalian cytotoxic T cells. The lab investigates how closely fish adaptive immunity matches that of mammals, aiming to contribute to vaccine development for farmed fish.
*Illustrative imageFish disease prevention using silk
Associate Professor Somamoto uses silk proteins to develop and evaluate administration technology for oral vaccines for farmed fish. The lab also works on research to prevent fish diseases using affinity silk.
*Illustrative imageInteraction between the coagulation system and innate immunity
Prof. Nakao investigates how the coagulation system and the innate immune system influence each other in fishes. The complement system is also listed among the research keywords.
MembersFaculty
- ProfessorMiki Nakao
- Associate ProfessorTomonori Somamoto
- Assistant ProfessorTakahiro Nagasawa
- Assistant ProfessorKIZHAKKUMPAT AKHIL
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Aquaculture in Chile” Gordon Leggett / CC BY-SA 4.0 (cropped)
- Diversification of the complement system in fishes: “09 Hegasy Complement System Wiki EN CCBYSA” Guido4 / CC BY-SA 4.0 (cropped)
- Adaptive immunity and cell-mediated immunity in fish: “A blood smear of rainbow trout” Bobjgalindo / CC BY 4.0 (cropped)
- Fish disease prevention using silk: “Silk fibers, Sopura Silk Mills Limited (01)” Moheen Reeyad / CC BY-SA 4.0 (cropped)
- Interaction between the coagulation system and innate immunity: “Blood clot” Yale Rosen / CC BY-SA 2.0 (cropped)
- Related lab (Aquatic Environmental Biology Lab): “Red algae bloom, Boathaven Bay, Airlie Beach IMGP0273” John Robert McPherson / CC BY-SA 4.0 (cropped)
- Related lab (Functional Water, Functional Foods, and Energy Lab (Endowed Chair)): “H2O Molecules as Water Vapor” Lizard125 / CC BY-SA 4.0 (cropped)
- Related lab (Fermentation Chemistry Lab): “Yeast cells in Gram stain” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (Insect Genome Science Lab): “Bombyx mori larvae, Bornholms Sommerfuglepark 21” Ole Palnatoke Andersen / CC BY-SA 3.0 (cropped)
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