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Synthetic Biology Lab
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The lab designs genes like programs to make microorganisms produce useful substances through synthetic biology.
AboutAbout the lab
Designing genes as if writing a program
The Synthetic Biology Lab studies the construction of synthetic gene circuits and synthetic metabolic pathways that produce substances such as bioalcohols.
Like writing a program, the lab designs gene sequences that behave as desired under specific conditions or produce a desired substance.
Microorganisms carrying the designed genes are created by recombinant DNA technology, then cultured to check their behavior and production.
When the results differ from what was intended, the gene sequences are redesigned using computational analysis.
Key terms
- Synthetic gene circuit
- An artificial system that controls gene function to make cells perform specified actions
- Synthetic metabolic pathway
- A series of chemical reactions for producing a target substance, artificially assembled inside a cell
- Recombinant DNA technology
- Recombinant DNA technology: a technique for artificially adding or replacing genes in an organism
NewsLab news
Paper on AI-based design of antifungal peptides accepted
A student won the Excellent Presentation Award at the Young Researchers' Meeting of Biotechnology
A student won the Student Award at the Kyushu Branch Meeting of the Society for Biotechnology, Japan
A student won the Student Excellent Presentation Award at the Annual Meeting of the Society for Biotechnology, Japan
Paper on AI-based design of MDH enzymes accepted
ResearchResearch themes
The lab aims to build synthetic gene circuits that control gene function, and synthetic metabolic pathways that produce useful substances such as bioalcohols. It creates and cultures microorganisms carrying the designed genes, and when they do not behave as intended, it redesigns the gene sequences using computational analysis.
*Illustrative imageBuilding synthetic gene circuits
The lab builds synthetic gene circuits that control gene expression and function using multiple biomolecules. Like writing a program, it designs gene sequences that behave as desired under specific conditions.
*Illustrative imageMetabolic pathways for producing useful substances
The lab builds synthetic metabolic pathways for producing useful substances such as bioalcohols. It creates microorganisms carrying the designed genes and cultures them to check whether they produce the desired substances.
*Illustrative imageAI-based design of enzymes and peptides
Using artificial intelligence, the lab works on designing short-sequence malate dehydrogenase and on searching for antifungal peptide candidates, and has published the results as papers.
MembersFaculty
- ProfessorTaizo Hanai
- Assistant ProfessorHiroyuki Hamada
- Assistant ProfessorKenshi Suzuki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Escherichia coli-Endo” Pavel Dušek / CC BY 3.0 (cropped)
- Building synthetic gene circuits: “Synthetic Biology Research at NASA Ames” Alexander van Dijk from San Francisco, United States / CC BY 2.0 (cropped)
- Metabolic pathways for producing useful substances: “Fermentation tanks in Forty Creek” Gogerr / CC BY-SA 4.0 (cropped)
- AI-based design of enzymes and peptides: “Computed Structure Models from AI and PDB Experimental Structures” Mariaurszula / CC BY 4.0 (cropped)
- Related lab (Nutrition Chemistry Lab): “Healthy Food - Colourful Fruit and Veg” formulatehealth / CC BY 2.0 (cropped)
- Related lab (Agrochemical Chemistry Lab): “Schlenk flask 500mL” Ichwarsnur / CC BY-SA 4.0 (cropped)
- Related lab (Microbial Technology Lab): “Joghurt” No machine-readable author provided. Rainer Zenz assumed (based on copyright claims). / CC BY-SA 3.0 (cropped)
- Related lab (Gene Regulation Lab): “Genome Sequencer2” Database Center for Life Science (DBCLS) / CC BY 3.0 (cropped)
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