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Quantum Biochemistry Lab
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A theory lab that studies the behavior of biomolecules, focusing on the role of the solvent.
AboutAbout the lab
Uncovering, through theory, the role of the solvent as a supporting player.
The Quantum Biochemistry Lab studies chemical and biological phenomena such as molecular motors, protein association, and electron transfer reactions, based on the methodology of physics.
Biopolymers such as proteins play the leading role in chemical reactions in living organisms, but their function depends on a supporting player: a suitable solvent.
The lab aims to uncover, from a theoretical standpoint, the fascinating side stories that solvents create.
Key terms
- Solvent
- The liquid in which a substance is dissolved. In this lab, it is treated as a supporting player that determines how dissolved biomolecules function.
- Molecular dynamics simulation
- A computational method that tracks the motion of atoms and molecules one by one on a computer to study how matter behaves.
- Integral equation theory
- A theory of statistical mechanics that finds how particles are distributed in a liquid by solving equations.
ResearchResearch themes
This lab investigates theoretically how solvents are involved in chemical reactions inside living organisms. Using simulations and theoretical calculations, it deals with the diffusion of large molecules and the forces acting between particles.
*Illustrative imageHow solvents support the function of biomolecules
Biopolymers such as proteins can perform their native functions only in a suitable solvent. For example, pepsin in the stomach works as an enzyme only in acidic gastric juice. The lab uncovers the role of the solvent from a theoretical standpoint.
*Illustrative imageDiffusion and hydration of large molecules
The lab uses molecular dynamics simulations to examine how hydration affects the diffusion of large molecules in water. It uses a method that divides a molecule's friction by site.
*Illustrative imageAttraction between like-charged particles
Using methods such as integral equation theory, the lab studies the effective attraction acting between particles carrying charges of the same sign in aqueous electrolyte solutions. It also addresses the mechanism by which the translational motion of solvent particles strengthens this attraction.
MembersFaculty
The members of the Quantum Biochemistry Lab are faculty members and students at the doctoral, master's, and undergraduate levels.As of 2026
- Associate ProfessorRyo Akiyama
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “A water droplet splash” Luke Peterson from Sydney, Australia / CC BY 2.0 (cropped)
- How solvents support the function of biomolecules: “H2O Molecules as Water Vapor” Lizard125 / CC BY-SA 4.0 (cropped)
- Diffusion and hydration of large molecules: “Simple & Facilitated Diffusion Across the Phospholipid Bilayer” Jiyapatel15 / CC BY-SA 4.0 (cropped)
- Attraction between like-charged particles: “SEM Image of Colloidal Particles” Yasrena / CC BY-SA 4.0 (cropped)
- Related lab (分散系物理化学研究室): “Water beads (42106)” Rhododendrites / CC BY-SA 4.0 (cropped)
- Related lab (構造機能生化学研究室): “Type ii nuclear receptor action” Boghog2 / Public domain (cropped)
- Related lab
(動的生命化学研究室): “Fluorescence from Fluorescent Proteins” Erin Rod / CC BY-SA 4.0 (cropped) - Related lab (生体分析化学研究室): “Cell membrane in Rheo leaf cell” Krishna satya 333 / CC BY-SA 4.0 (cropped)
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