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Dynamic Life Chemistry Lab
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The lab uses fluorescence to observe how proteins move and to investigate biological phenomena.
AboutAbout the lab
Visualizing protein dynamics to decode biological phenomena.
The Dynamic Life Chemistry Lab develops chemical biology techniques that visualize proteins using synthetic fluorescent molecules.
Inside cells, countless biomolecules change location and work where they are needed, regulating the physiological functions of the cell.
Using its original protein labeling technology, the lab aims to clarify how proteins move inside living cells and how they regulate biological phenomena.
The lab also aims to elucidate biological phenomena regulated by nucleic acids, glycans, and extracellular vesicles, and to freely control the functions of biomolecules.
Key terms
- Chemical biology
- A field that uses the principles and tools of chemistry to study phenomena that occur in living organisms.
- PYP tag
- An original tag protein fused to a target protein. Synthetic fluorescent probes specifically label it.
- Fluorogenic probe
- A synthetic molecule that becomes fluorescent as a result of the labeling reaction.
- GLUT4
- A type of glucose transporter that takes glucose from the blood into cells.
NewsLab news
View More ↗ResearchResearch themes
The lab aims to use synthetic fluorescent molecules to clarify how biomolecules such as proteins move inside living cells and regulate biological phenomena. It is also extending its protein labeling technology to research on nucleic acids, glycans, and extracellular vesicles, with the goal of freely controlling the functions of biomolecules.
*Illustrative imageProtein labeling with the PYP tag
A PYP tag attached to a target protein is labeled with a fluorogenic probe that becomes fluorescent upon labeling, which makes the protein's movement visible. The lab is now developing probes that allow faster, higher-contrast imaging.
*Illustrative imageMechanisms that control GLUT4 movement
The lab visualized GLUT4, which lowers blood glucose levels, moving to the cell membrane, and found that glycans play a role in holding GLUT4 at the cell membrane. It is now investigating the detailed mechanism to gain insights useful for diabetes treatment.
*Illustrative imageVisualizing protein degradation
The lab developed 'OFF-ON-OFF fluorescent probes,' which become fluorescent upon labeling and lose their fluorescence again when the protein is degraded, and has succeeded in visualizing degradation. It is now developing technology for more sensitive detection.
*Illustrative imageVisualizing nucleic acid modifications
The lab created hybrid probes composed of a synthetic dye and a protein inside cells. Their fluorescence intensifies when they bind to methylated DNA, which allowed the lab to visualize the movement of methylated DNA in living cells. It is now extending the technology to other chemical modifications of nucleic acids.
MembersFaculty
The members of the Dynamic Life Chemistry Lab are faculty members and PhD, master's, and undergraduate students.As of 2026
- ProfessorYuichiro Hori
- Associate ProfessorKanae Yumimoto
- Assistant ProfessorShogo Sasaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fluorescence from Fluorescent Proteins” Erin Rod / CC BY-SA 4.0 (cropped)
- Protein labeling with the PYP tag: “Tsien lab fluorescent proteins” Erik Rodriguez / CC BY-SA 4.0 (cropped)
- Mechanisms that control GLUT4 movement: “GLUT4signalingpathway” Leon Peifer-Weiß, et al / CC BY 4.0 (cropped)
- Visualizing protein degradation: “Proteasome cutaway 2” Opabinia regalis / CC BY-SA 3.0 (cropped)
- Visualizing nucleic acid modifications: “Zybio Nucleic Acid Extraction machine” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (Bioorganic Chemistry Lab): “Biology apparatus” Abdsomod / CC0 (cropped)
- Related lab (Bioanalytical Chemistry Lab): “Cell membrane in Rheo leaf cell” Krishna satya 333 / CC BY-SA 4.0 (cropped)
- Related lab (Biomolecular Chemistry Lab): “Molymods” Sonia / CC BY 3.0 (cropped)
- Related lab (Biocatalytic Chemistry Lab): “Plantes médicinales planche 1 - Medicinal plants, medical herbs, botanical illustrations, plate 1 - Public domain illustration from Larousse du XXème siècle 1932” EN NOIR & BLANC / CC0 (cropped)
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