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Bioanalytical Chemistry Lab
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A lab that explores how biological membranes work, using analytical chemistry and organic chemistry.
AboutAbout the lab
Without biological membranes, there would be no life.
The Bioanalytical Chemistry Lab studies the structures and functions of biological membranes by combining analytical chemistry and organic chemistry (chemical biology).
Because many commercially available drugs act on membrane proteins and lipid membranes, the lab aims to extend techniques from biological membrane research to clarifying how drugs work, diagnosing diseases, and drug discovery.
In running the lab, it takes "improving quality of life (QOL)" as a keyword, and it offers orientation courses and hands-on experimental guidance so that newly assigned students can start their research with confidence.
Its research equipment includes NMR, mass spectrometers, and capillary electrophoresis systems.
Key terms
- Biological membrane
- A membrane that separates internal organs from the outside world; it is made of lipids, proteins, sugar chains, and other components
- Membrane protein
- A protein found in a biological membrane; many drugs target these proteins
- Lipid raft
- A tiny assembly of lipids and proteins formed within a biological membrane; thought to be involved in signal transduction and viral infection
- Lipid asymmetry
- The state in which the lipid composition differs between the inner and outer leaflets of a biological membrane
NewsLab news
A paper was published on a new membrane control technology that uses the meshing of triptycenes
A paper was published on a new technique for directly observing phospholipids containing docosahexaenoic acid
A master's student received a Best Presentation Award and other honors at MSB2026
A master's student received an Excellent Presentation Award and an Excellent Poster Presentation Award at the Capillary Electrophoresis Symposium
A paper was published on the development of a simple assay for cell membrane permeability
ResearchResearch themes
Biological membranes play vital roles in life, such as signal transmission, yet they are extremely complex systems in which lipids, proteins, sugar chains, and other components change dynamically through weak interactions. The lab takes its own approach, using organic chemistry (chemical biology) and analytical chemistry, to uncover the structures and functions of biological membranes.
*Illustrative imageInteractions between lipids and membrane proteins
Lipids are thought to regulate the functions of membrane proteins. The lab has developed its own methods to comprehensively and simply identify membrane proteins that interact with specific lipids and lipids that interact with specific membrane proteins, and has also begun research that leads to drug discovery.
*Illustrative imageAnalysis of lipid rafts
The lab studies how lipid rafts are formed and what roles they play in cells. It chemically synthesizes lipids labeled with fluorescent tags or stable isotopes and analyzes them using confocal microscopy and solid-state NMR. It also focuses on lipid asymmetry, in which the lipid composition differs between the inner and outer leaflets.
Mechanisms of action of anesthetics and natural products
Anesthetics act on lipid membranes and membrane proteins, but their mechanism has not been clarified. The lab aims to elucidate it using a variety of analytical methods, and has obtained results suggesting that lipid rafts are involved in anesthetic action. It also analyzes the mechanisms of action of natural organic compounds that act on membranes and membrane proteins.
*Illustrative imageDevelopments that make organic synthesis more convenient
The Torikai team aims to develop reagents, synthetic methods, and tools that make organic synthetic chemistry a little more convenient and that other researchers can also use. It targets the synthesis of molecules that act on living organisms and of their model molecules, and carries out this work while discussing in English with overseas collaborators and international students.
MembersFaculty
The members of the Bioanalytical Chemistry Lab are faculty, technical assistants, doctoral, master's, and undergraduate students, and research students.As of 2026
- ProfessorNobuaki Matsumori
- LecturerKohei Torikai
- Assistant ProfessorYo Yano
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cell membrane in Rheo leaf cell” Krishna satya 333 / CC BY-SA 4.0 (cropped)
- Interactions between lipids and membrane proteins: “RBC membrane major proteins-ar” Ernst Hempelmann / CC0 (cropped)
- Analysis of lipid rafts: “Lipid Raft” Lizanne Koch lgkoch / Public domain (cropped)
- Developments that make organic synthesis more convenient: “-chemistry lab -conical -droplet -liquid testing” Govindaraj Mahalakshmi / CC BY-SA 4.0 (cropped)
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