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Bioorganic Chemistry Lab
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The lab investigates how natural products exert their biological activity and designs new drugs.
AboutAbout the lab
Uncovering how natural products work to design new drugs.
The Bioorganic Chemistry Lab studies the principles by which compounds isolated from animals, plants, and microorganisms that show strong biological activity exert that activity.
Some of these compounds act on biological membranes or specific proteins, and are used as antibiotics and anticancer drugs.
Based on the principles behind the activity, the lab works on the molecular design, chemical synthesis, and activity evaluation of new drugs.
The lab's keywords are natural products chemistry, synthetic organic chemistry, and chemical biology.
Key terms
- Ladder-shaped polyether
- A natural product with a structure in which cyclic ethers are linked in a row like a ladder. Maitotoxin is one example.
- Microflow reactor
- A new device used instead of a flask. It makes it possible to use unstable intermediates that could not be controlled in conventional reactions.
- Amphidinol 3
- An antifungal substance produced by dinoflagellates. The lab focuses on it as a new type of antimicrobial agent unlike existing ones.
NewsLab news
A master's student received an Excellent Poster Presentation Award at the 63rd Joint Kyushu Convention of Chemistry-Related Branches
A presentation by the lab was selected as a highlight lecture at the 106th Annual Meeting (Spring) of the Chemical Society of Japan
ResearchResearch themes
The lab seeks to clarify the principles by which compounds isolated from animals, plants, and microorganisms exert strong biological activity by acting on biological membranes or specific proteins. Based on these principles, it works on the molecular design, chemical synthesis, and activity evaluation of new drugs.
*Illustrative imageSynthesis and Mechanism of Action of Ladder-Shaped Polyethers
Maitotoxin has a biological activity that increases intracellular Ca2+ concentration at extremely small doses, but the details are not understood. Through chemical synthesis of this rare natural product and preparation of molecular probes, the lab aims to identify the target proteins through which it acts.
*Illustrative imageUsing Microflow Reactors
Using a new device called a microflow reactor instead of a flask has made it possible to use unstable intermediates that could not be controlled in conventional organic reactions. The lab applies this approach to the synthesis of natural products.
*Illustrative imageDeveloping Antimicrobial Agents That Act on Cell Membranes
As the emergence of resistant bacteria against which antibiotics are ineffective becomes a social problem, the lab focuses on amphidinol 3, an antifungal substance produced by dinoflagellates. It develops an efficient synthetic method and aims to create simplified analog molecules based on structure-activity relationships.
MembersFaculty
The members of the Bioorganic Chemistry Lab consist of faculty members and doctoral, master's, and undergraduate students.As of 2026
- ProfessorTohru Oishi
- Associate ProfessorHiroshi Tsuchikawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Biology apparatus” Abdsomod / CC0 (cropped)
- Synthesis and Mechanism of Action of Ladder-Shaped Polyethers: “Red tide＿2017” melvil / CC BY-SA 4.0 (cropped)
- Using Microflow Reactors: “Uniqsis-FlowSyn Flow Reactor” Martyn Fordham / Public domain (cropped)
- Developing Antimicrobial Agents That Act on Cell Membranes: “Transport of Molecules Across the Cell Membrane by Endocytosis and Exocytosis (1)” Sinigangalang / CC BY-SA 4.0 (cropped)
- Related lab (Biocatalytic Chemistry Lab): “Plantes médicinales planche 1 - Medicinal plants, medical herbs, botanical illustrations, plate 1 - Public domain illustration from Larousse du XXème siècle 1932” EN NOIR & BLANC / CC0 (cropped)
- Related lab (Dynamic Life Chemistry Lab): “Fluorescence from Fluorescent Proteins” Erin Rod / CC BY-SA 4.0 (cropped)
- Related lab (Organic Reaction Chemistry Lab): “Crystallisation? Reaction? Don't remember ( )” Максим Фомич / CC BY 2.0 (cropped)
- Related lab (Structural Organic Chemistry Lab): “Supramolecular pyrene derivative nanorods laying on covalently bonded pyrene derivative aggregate” Bzitoo / CC BY-SA 4.0 (cropped)
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