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Functional Structure Measurement Lab
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The lab makes solid-state NMR ultra-sensitive in order to explore the structure and function of proteins.
AboutAbout the lab
Making visible what cannot normally be seen.
The Functional Structure Measurement Lab uses solid-state nuclear magnetic resonance (NMR) to investigate, at atomic resolution, the three-dimensional structures, chemical structures, and dynamics of insoluble and non-crystalline materials and molecular assemblies.
The lab also builds instruments and methods for spin hyperpolarization (DNP), making it possible to observe extremely small amounts of molecules that were previously invisible because of limited sensitivity.
It has also developed nanodiamond polarizing agents that do not lose activity inside cells, as well as a nano-space selection method that picks out and observes only the target molecules, enabling highly sensitive observation of targets even in crowded environments.
These technologies are widely applied in research in biology, chemistry, and materials science.
Key terms
- Solid-state nuclear magnetic resonance (NMR)
- A measurement method that investigates the three-dimensional structure, chemical structure, and dynamics of insoluble or non-crystalline samples at atomic resolution
- Spin hyperpolarization (DNP)
- A technique for greatly increasing the sensitivity of NMR, which makes it possible to observe extremely small amounts of molecules
- Nano-space selection method
- A method that picks out and observes only the target molecules in a crowded environment
ResearchResearch themes
The lab develops measurement technologies, centered on solid-state NMR, that make visible what cannot normally be seen. It also aims to elucidate, based on the three-dimensional structures of molecules, how the physiological functions of proteins are expressed and how they sustain life processes.
*Illustrative imageUltra-high-sensitivity solid-state NMR measurement technologies
The lab builds instruments and methods for spin hyperpolarization (DNP) and has succeeded in making solid-state NMR ultra-sensitive. With nanodiamond polarizing agents that do not lose activity inside cells and the nano-space selection method, it can observe only the target with high sensitivity even in crowded environments.
*Illustrative imageStructural biology of proteins
The lab seeks to elucidate how proteins carry out life processes, based on the three-dimensional structures of the molecules. Combining NMR with computational methods, it focuses on structural studies of membrane proteins involved in ion transport and signal transduction, and of polymers of pathogenic filamentous proteins.
*Illustrative imageDevelopment of new measurement methods and instruments
Solution NMR has the weakness that it cannot analyze large systems above a certain molecular weight, and advances in solid-state NMR can overcome this. The lab develops new measurement methods and instruments with the goal of directly analyzing giant biomolecules, supramolecular systems, and the inside of cells.
MembersFaculty
- Associate ProfessorYoh Matsuki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “900 MHz unshielded Oxford magnet Svenskt NMR centrum Gothenburg” Adville / CC BY-SA 4.0 (cropped)
- Ultra-high-sensitivity solid-state NMR measurement technologies: “Bruker Ultrashield 500 MHz WB Plus Solid State NMR” Diasfrederico / CC BY-SA 4.0 (cropped)
- Structural biology of proteins: “2k49 NMR ensemble ribbons” Jane Richardson (Dcrjsr) / CC BY 3.0 (cropped)
- Development of new measurement methods and instruments: “NMR spectrometer” Daniel Alexandre / CC BY-SA 3.0 (cropped)
- Related lab (Electron Structural Biology Lab): “FEI Titan 50-300 PICO” ER-C, Forschungszentrum Jülich / CC BY-SA 4.0 (cropped)
- Related lab (Protein Crystallography Lab (Kurisu Lab)): “SHOC2 Protein Crystal Structure” Achaparro0600 / CC BY-SA 4.0 (cropped)
- Related lab (Spin Structural Biology Lab): “NMR instrument” SamihaAlam1999 / CC BY-SA 4.0 (cropped)
- Related lab (Higher Brain Function Lab): “Histology of thalamic neuron” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
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