Labs in The University of Osaka, Graduate School of Engineering, Department of Materials and Manufacturing Science, Cooperative Chair

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The lab uses an ultrahigh-voltage electron microscope to reveal the structures of biological macromolecules.

The Life Science Lab (Mitsuoka Lab) uses an ultrahigh-voltage electron microscope to carry out high-resolution structural analysis of biological macromolecules and their complexes inside cells. A key feature of the ultrahigh-voltage electron microscope is that it can observe thick specimens. The lab uses rapid freezing to fix biological macromolecules as they are in ice, and examines their structures by cryo-electron microscopy. From these structures, the lab clarifies structural changes and localization inside cells, deepening basic understanding of life science while also conducting research toward engineering applications of biological macromolecules. The lab is one of the research fields of the Research Center for Ultra-High Voltage Electron Microscopy at Osaka University.

#Cryo-electron microscopy #Biopolymers #Structural analysis