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抗体医薬設計学分野
Showing the original Japanese · View translation
抗体の結合の仕方から次世代の抗体医薬を設計する研究室。
AboutAbout the lab
抗体の結合の仕方から、次世代の抗体医薬を設計する。
抗体医薬設計学分野は、
独自の
がん、
研究室の
Key terms
- エピトープ
- 抗原の
表面で、 抗体が 結合する 部位。 抗体側の 結合 部位は パラトープと 呼ばれる - 結合
モード - 抗体が
標的の どの 部位に、 どの 角度で 結合するかと いう 結合の 仕方。 機能や 性質の 違いを 生む - エピトープ均質化抗体パネル
- 抗原表面の
異なる エピトープを 網羅的に 認識する 抗体群を、 体系的に そろえた 研究室独自の 技術 - GPCR
- 細胞膜を
何度も 貫通する 膜タンパク質の 一種。 さまざまな 病気で 体の 働きを 調節する 創薬標的
ResearchResearch themes
抗体は、
*Illustrative image創薬が難しい標的への抗体づくり
GPCRなどの
*Illustrative image抗体工学で薬効を高める設計
制御性T細胞や
*Illustrative imageAIによる構造モデリングと設計指針
AIを
*Illustrative image免疫応答を創薬資源にするエピトープ分類
免
MembersFaculty
抗体医薬設計学分野の
- Project Leader永田 諭志
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Tislelizumab PB-1 7BXA” Fvasconcellos (talk · contribs) / Public domain (cropped)
- 創薬が
難しい 標的への 抗体づくり: “Muscarinic receptor M2 coupled to protein G - 6OIK” Vcilleros / CC BY-SA 4.0 (cropped) - 抗体工学で
薬効を 高める 設計: “Alnuctamab” Jennifer Reilly / Public domain (cropped) - AIに
よる 構造モデリングと 設計指針: “Computed Structure Models from AI and PDB Experimental Structures” Mariaurszula / CC BY 4.0 (cropped) - 免疫応答を
創薬資源に する エピトープ分類: “Antibody IgG1 surface” Tokenzero / CC BY-SA 4.0 (cropped)
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