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Molecular Pathology Lab
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A molecular pathology lab that searches for clues to the diagnosis and treatment of cancer.

AboutAbout the lab
Tackling cancer from both cells and clinical specimens.
The Molecular Pathology Lab studies the nature of cancer, in the hope that its findings will lead to better cancer diagnosis and treatment.
Through both cell experiments and research on clinical materials, meaning specimens from patients, the lab aims to attack cancer from two sides.
The professor likens cancer tissue to a city invaded by a foreign organism.
The lab believes that molecular biology techniques that analyze DNA, RNA, and epigenetics are useful for investigating the character of cancer.
Key terms
- Epigenetics
- Epigenetics: a field that deals not with the DNA sequence itself but with changes such as DNA methylation and histone acetylation.
- microRNA
- microRNA: a type of short RNA. The lab examines its expression level as an indicator of cancer prognosis and also studies its use in nucleic acid therapy.
- Cancer stem cells
- Cancer stem cells: special cells within cancer tissue. The lab searches for their specific markers and for molecules that could serve as therapeutic targets.
ResearchResearch themes
This lab investigates markers of cancer prognosis and diagnosis, cancer stem cells, and abnormalities in cancer cell signal transduction. Experiments use techniques such as immunostaining, gene analysis, cell experiments, and experiments with tumor-bearing mice.
*Illustrative imageSearching for new prognostic markers
The lab looks for new markers that indicate cancer prognosis, using molecule-specific immunostaining and the expression levels of mRNA and microRNA as clues.
*Illustrative imageSearching for cancer diagnostic markers
The lab searches for diagnostic markers in gene mutations and abnormal expression of RNA and proteins, as well as in epigenetic abnormalities such as DNA promoter methylation, microRNA, long non-coding RNA, and histone acetylation and demethylation.
*Illustrative imageExploring the properties of cancer stem cells
The lab searches for markers specific to cancer stem cells. It also aims to identify molecules that can serve as therapeutic targets for cancer stem cells and to develop treatments.
*Illustrative imageExploring abnormalities in cancer cell signal transduction
The lab explores cancer treatment by correcting abnormal signaling. It is also developing companion diagnostics that assess compatibility with the cancer tissue, and patient-specific nucleic acid therapies using microRNA and siRNA.
MembersFaculty
The Molecular Pathology Lab consists of faculty members, project lecturers, visiting faculty, project researchers, doctoral, master's, and undergraduate students, research students, students in gastroenterological surgery, and administrative assistants.As of 2025
- ProfessorHirofumi Yamamoto
- Internal LecturerYuki Yokoyama
- Project LecturerSatoshi Shibata
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Part of whole slide image of a Wilms' tumor of the kidney” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / Public domain (cropped)
- Searching for new prognostic markers: “P63 staining on prostate cancer tissue using antibody clone IHC063” GenomeMe Lab Inc. / CC BY 4.0 (cropped)
- Searching for cancer diagnostic markers: “Eppendorf Mastercycler Pro S” GFJ / CC BY-SA 4.0 (cropped)
- Exploring the properties of cancer stem cells: “Cancer stem cells model” Malymajo / CC BY-SA 3.0 (cropped)
- Exploring abnormalities in cancer cell signal transduction: “Immunohistochemistry of adenocarcinoma with nuclear staining for TTF-1” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Related lab (Acute and Palliative Care Lab): “Patient lying in hospital bed in intensive care unit in Germany in 2015” Pittigrilli / CC BY-SA 4.0 (cropped)
- Related lab (Perioperative Management Lab): “AusMAT team members performing surgery ( )” Department of Foreign Affairs and Trade / CC BY 2.0 (cropped)
- Related lab (Psychiatric and Mental Health Nursing Lab): “Nursing staff, St Mary's Hospital” Ardosion / CC BY-SA 4.0 (cropped)
- Related lab (Chronic Illness Nursing Lab): “Nurse checks blood pressure” Linda Bartlett (Photographer) / Public domain (cropped)
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