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Pathogenic Microbiology and Microbiome Lab
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The lab investigates infectious diseases through the actions of pathogenic bacteria and resident bacteria.

AboutAbout the lab
Studying microbiology to reduce the threat of infectious diseases.
The Pathogenic Microbiology and Microbiome Lab conducts research and education in microbiology to contribute to the eradication of infectious diseases and the reduction of their threat.
At the molecular level, the lab investigates the virulence of pathogenic bacteria such as streptococci, and how changes in the microbiome of the gut, skin, and oral cavity relate to disease.
In education, the lab teaches pathogenic microbiology to undergraduate and graduate students in health sciences, aiming to train researchers and healthcare professionals who can act on their own to solve problems related to infectious diseases.
On the lab's website, the lab is introduced under the name "Okamoto Lab".
Key terms
- Microbiome
- A collection of many types of bacteria living in places such as the gut, skin, and oral cavity. The lab studies how changes in its composition relate to disease.
- Fulminant streptococcal infection
- An infection reported to be caused by Group A and Group G streptococci, with cases and deaths occurring one after another.
- Opportunistic infection
- An infection that is common in people with weakened immunity.
ResearchResearch themes
The lab aims to clarify the actions of pathogenic bacteria that cause infectious diseases and of bacteria that normally live in the body, and to apply this knowledge to prevention, treatment, and rapid testing methods. Its research topics are the virulence of streptococci, vancomycin-resistant enterococci, and the relationship between changes in the resident microbiota and disease.
*Illustrative imageVirulence and Virulence Factors of Streptococci
The lab investigates the virulence and virulence factors of Group A and Group G streptococci isolated from cases of fulminant streptococcal infection. It also studies the mechanism by which co-infection with influenza virus leads to fulminant Group A streptococcal infection.
*Illustrative imageVirulence of Vancomycin-Resistant Enterococci
The lab has started research on vancomycin-resistant enterococci (VRE), which are resistant to the antibiotic vancomycin, examining the types that spread infection, their properties, and the mechanism by which they colonize the gut.
*Illustrative imageRelationship Between Changes in Resident Microbiota and Disease
The lab investigates the causal relationship between changes in the composition of the resident microbiota of the skin, mucous membranes, gut, and oral cavity and diseases such as opportunistic infections. Its goal is to establish evidence-based measures for prevention and palliative care.
MembersFaculty
The members of the Pathogenic Microbiology and Microbiome Lab consist of faculty, doctoral and master's students, and undergraduate special research students.As of 2025
- ProfessorShigefumi Okamoto
- Assistant ProfessorMasashi Yanagihara
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Common laboratory contaminant fungus, Mucor grew on blood agar plate in Microbiology laboratory” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Virulence and Virulence Factors of Streptococci: “Streptococcus pyogenes 01” Photo Credit: Content Providers(s) / Public domain (cropped)
- Virulence of Vancomycin-Resistant Enterococci: “Vancomycin-Resistant Enterococcus 01” Photo Credit: Janice Haney Carr Content Providers: CDC/ Janice Haney Carr / Public domain (cropped)
- Relationship Between Changes in Resident Microbiota and Disease: “Gut microbiota composition” Muséum d'histoire naturelle de Toulouse / CC BY-SA 3.0 (cropped)
- Related lab (Acute and Palliative Care Lab): “Patient lying in hospital bed in intensive care unit in Germany in 2015” Pittigrilli / CC BY-SA 4.0 (cropped)
- Related lab (Perioperative Management Lab): “AusMAT team members performing surgery ( )” Department of Foreign Affairs and Trade / CC BY 2.0 (cropped)
- Related lab (Psychiatric and Mental Health Nursing Lab): “Nursing staff, St Mary's Hospital” Ardosion / CC BY-SA 4.0 (cropped)
- Related lab (Chronic Illness Nursing Lab): “Nurse checks blood pressure” Linda Bartlett (Photographer) / Public domain (cropped)
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