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Regenerative Medicine and Developmental Biology Lab
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The lab studies eye regeneration and development, photoreceptor pathology, and genetics.
AboutAbout the lab
Exploring eye regeneration and disease mechanisms through genes.
Centering on ophthalmology, the Regenerative Medicine and Developmental Biology Lab studies regenerative medicine for the cornea, eye development, photoreceptor pathology, and the causative genes of hereditary diseases.
The lab belongs to the Department of Biopathological Information Science, in the Medical Technology Sciences field of the Division of Health Sciences, Graduate School of Medicine, Osaka University.
In its research, the lab uses human iPS cells, zebrafish, model mice, and other models.
Prof. Tsujikawa is a physician who has treated patients and studied diseases in ophthalmology, and in the lab he also teaches anatomy and clinical chemistry in lectures and practical training.
Key terms
- Photoreceptor cells
- Nerve cells specialized for detecting light. The death of these cells leads directly to blindness.
- Zebrafish
- A type of fish. In this lab, it is used as a model to study how photoreceptor cells die, through genetic manipulation.
- iPS cells
- Artificial cells that can be turned into many types of cells. In this lab, human cells are used in research on eye development.
- Gelatinous drop-like corneal dystrophy
- A hereditary corneal disease that is difficult to treat. Prof. Tsujikawa isolated its causative gene in his doctoral thesis.
NewsLab news
A student received an Excellent Poster Award at the Advanced Animal Model Support Platform results presentation meeting
A student received the MBSJ Poster Award 2025 at the 48th Annual Meeting of the Molecular Biology Society of Japan
A student received the Silver Award (oral presentation) at the 28th Ophthalmic Molecular Biology Research Meeting
A student received an Excellent Poster Award at the Advanced Animal Model Support Platform results presentation meeting
The lab published materials introducing the lab atmosphere for incoming fourth-year students
ResearchResearch themes
The field of ophthalmology covers a wide range of research themes, including nerves, blood vessels, and genetic diseases. Making use of this strength, the lab is considering broadening its range of research, and it currently works on regeneration and development, the pathology of sensory neurons, and human genetics research.
*Illustrative imageResearch on Eye Regeneration and Development
In corneal regenerative medicine, the Department of Ophthalmology in the School of Medicine plans to start a treatment using epithelial cells derived from iPS cells, and the lab will take part in the basic and clinical research. The lab is also using human iPS cells to study the mechanisms of development, with the eyeball as the unit of study.
*Illustrative imagePathology of Sensory Neurons Such as Photoreceptor Cells
The lab investigates how photoreceptor cells, which detect light, die, using genetic manipulation of zebrafish. Part of this work is conducted as joint research with a pharmaceutical company, as a potential drug target. The lab also conducts research on the molecular pathology of the nervous system, not limited to photoreceptor cells.
*Illustrative imageDisease Research Through Human Genetics
In his doctoral thesis, Prof. Tsujikawa isolated the causative gene of gelatinous drop-like corneal dystrophy, a hereditary corneal disease that is difficult to treat. Since then, he has studied the pathology and treatment of this disease, including with model mice, and has also investigated causative genes and susceptibility genes for diseases.
MembersFaculty
The members of the Regenerative Medicine and Developmental Biology Lab consist of faculty and doctoral, master's, and undergraduate students.As of 2026
- ProfessorMotokazu Tsujikawa
- Associate ProfessorShigeru Sato
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “"CORNEA UNIVERSE"” Anselmuccifederico / CC BY 4.0 (cropped)
- Research on Eye Regeneration and Development: “Cornea of eye” Zrynah / CC BY-SA 4.0 (cropped)
- Pathology of Sensory Neurons Such as Photoreceptor Cells: “ConeMosaics” Mark Fairchild / CC BY-SA 3.0 (cropped)
- Disease Research Through Human Genetics: “Laboratory reactives for Sanger sequencing” LuisCG11 / CC BY-SA 4.0 (cropped)
- Related lab (Acute and Palliative Care Lab): “Patient lying in hospital bed in intensive care unit in Germany in 2015” Pittigrilli / CC BY-SA 4.0 (cropped)
- Related lab (Perioperative Management Lab): “AusMAT team members performing surgery ( )” Department of Foreign Affairs and Trade / CC BY 2.0 (cropped)
- Related lab (Psychiatric and Mental Health Nursing Lab): “Nursing staff, St Mary's Hospital” Ardosion / CC BY-SA 4.0 (cropped)
- Related lab (Chronic Illness Nursing Lab): “Nurse checks blood pressure” Linda Bartlett (Photographer) / Public domain (cropped)
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