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Clinical Neurophysiology Lab
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The lab investigates rare intractable neurological and muscular diseases using electrophysiology and genetics.
AboutAbout the lab
Rare disease research that begins with electrophysiology.
The Clinical Neurophysiology Lab studies the mechanisms of diseases of the brain, nerves, and muscles, centering on physiological methods such as electrophysiology and also using genetic analysis.
The lab is working to clarify disease mechanisms using patient-derived iPS cells, and it also conducts research on treatments, mainly for rare diseases caused by ion channel abnormalities.
The lab also runs a patient registry (a register of patients) and is building the foundation needed for developing treatments.
The master's program in the Division of Health Sciences has a genetic counseling course, through which the lab trains certified genetic counselors.
Key terms
- Ion channel
- A gateway in the cell membrane that allows electrically charged particles (ions) to pass through. It is involved in the electrical activity of nerves and muscles.
- Patient registry
- A system for registering and collecting patient information. It serves as a foundation for treatment development, including epidemiological and natural history studies.
- Patch clamp method
- An electrophysiological technique that measures the electric current flowing through channels in the cell membrane. It is used to examine the function of mutated channels.
ResearchResearch themes
The lab targets diseases of the brain, nerves, and muscles, especially rare intractable diseases with few patients, and aims to clarify disease mechanisms through physiological and genetic analysis. While valuing its connections with patients, the lab also works on building the foundation for treatment development.
*Illustrative imageResearch on Patient QOL and Registries
From the standpoint of laboratory medicine, the lab also works on assessing patients not merely as biological "humans" but as "people", placing importance on communication. For rare intractable diseases, accumulating patients' real-world data provides essential data for developing therapeutic drugs.
*Illustrative imageGenome Research on Rare Neuromuscular Intractable Diseases
Focusing on diseases involving ion channel abnormalities, such as periodic paralysis and myotonic dystrophy, the lab works on diagnosis, identification of new causative genes, and clarification of disease mechanisms at the DNA and RNA levels. It also investigates susceptibility genes for sporadic diseases such as myasthenia gravis.
*Illustrative imageDisease Research Through Channel Function Analysis
To determine whether a new mutation found in a patient is related to disease, the lab examines the function of the mutant channel using electrophysiological methods such as patch clamp, and verifies the results with computer simulation. It also studies how channels and receptors expressed in cells such as lymphocytes are involved in neuromuscular immune diseases.
MembersFaculty
The members of the Clinical Neurophysiology Lab consist of faculty, concurrent and visiting faculty, project researchers, doctoral, master's, and undergraduate students, and technical assistants.As of 2025
- ProfessorMasanori Takahashi
- Associate ProfessorTomoya Kubota
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Nerve conduction velocity” Private individual / CC BY-SA 3.0 (cropped)
- Research on Patient QOL and Registries: “Blood donation (test tubes)” Vegasjon / CC BY-SA 4.0 (cropped)
- Genome Research on Rare Neuromuscular Intractable Diseases: “GelDoc DNA gel electrophoresis photograph stained with ethidium bromide 04” Sgroey / CC BY-SA 4.0 (cropped)
- Disease Research Through Channel Function Analysis: “Patch clamp schematic 1” PeaBrainC / CC BY-SA 4.0 (cropped)
- Related lab (Acute and Palliative Care Lab): “Patient lying in hospital bed in intensive care unit in Germany in 2015” Pittigrilli / CC BY-SA 4.0 (cropped)
- Related lab (Perioperative Management Lab): “AusMAT team members performing surgery ( )” Department of Foreign Affairs and Trade / CC BY 2.0 (cropped)
- Related lab (Psychiatric and Mental Health Nursing Lab): “Nursing staff, St Mary's Hospital” Ardosion / CC BY-SA 4.0 (cropped)
- Related lab (Chronic Illness Nursing Lab): “Nurse checks blood pressure” Linda Bartlett (Photographer) / Public domain (cropped)
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