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Cardiovascular Metabolism Lab
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The lab explores the mechanisms of lifestyle-related diseases through the functions of adipocytes.
AboutAbout the lab
Unraveling the mechanisms of lifestyle-related diseases through adipocyte function
The Cardiovascular Metabolism Lab studies the original functions of adipocytes (fat cells) and how their dysregulation leads to obesity.
Aiming to overcome lifestyle-related diseases, the lab focuses on the pathology of obese adipose tissue and the functions of adipocytokines secreted by adipocytes.
The lab regards adipocytes as cells that not only store energy but also regulate their own functions through their own nutrient signals, and it works to clarify these mechanisms.
The lab belongs to the Department of Pathophysiological Information Science in the Division of Health Sciences, Graduate School of Medicine, Osaka University.
Key terms
- Adipocytokine
- A substance produced and secreted by adipocytes. Examples include the beneficial adiponectin
- Insulin resistance
- A condition in which insulin, the hormone that lowers blood glucose, becomes less effective
- Oxidative stress
- A state in which enzymes that produce reactive oxygen species increase and the activity of antioxidant enzymes decreases. It occurs chronically in obese adipose tissue
ResearchResearch themes
Adipocytes play a central role in maintaining the body's condition by storing energy when there is a surplus and releasing it when there is a shortage. The lab investigates both their original functions and how dysregulation of those functions leads to obesity, through analysis of obese adipose tissue and functional analysis of adipocytokines.
*Illustrative imageOxidative Stress and Hypoxia in Obese Adipose Tissue
In obese adipose tissue, oxidative stress is chronically elevated, leading to insulin resistance and visceral fat accumulation. Hypoxia, which occurs when angiogenesis cannot keep up with adipocyte hypertrophy, also triggers abnormal secretion of adipocytokines.
*Illustrative imageFunctional Analysis of Adipocytokines and Secreted Factors
The lab clarified that SDF-1, released by adipocytes, is a factor that suppresses the insulin sensitivity of the adipocytes themselves. Favine, a newly identified secreted factor, promotes adipocyte differentiation and triglyceride accumulation, and atherosclerosis worsens in knockout mice lacking it.
*Illustrative imageRegulation of Adipocytes by Nutrient Signals
The lab found that ketone bodies are involved in the mechanism by which SGLT2 inhibitors, a class of diabetes drugs, increase the beneficial adiponectin. It is working to clarify new mechanisms of adipocyte regulation by nutrient signals such as ketone bodies, glutamine, and lactate.
*Illustrative imageDevelopment of Novel Biomarkers
In diabetes and obesity, activation of the mineralocorticoid receptor causes vascular fibrosis and inflammation, but there has been no effective indicator of it. The lab is developing an assay to measure its activity using urine-derived exosomes, aiming to establish a new risk assessment factor for atherosclerosis.
MembersFaculty
The members of the Cardiovascular Metabolism Lab are faculty, doctoral students, and undergraduate students.As of 2026
- ProfessorAtsunori Fukuhara
- Associate ProfessorHiroyasu Yamamoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Connective Tissue Adipose ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Oxidative Stress and Hypoxia in Obese Adipose Tissue: “Blausen 0012 AdiposeTissue” BruceBlaus. When using this image in external sources it can be cited as: Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN . / CC BY 3.0 (cropped)
- Functional Analysis of Adipocytokines and Secreted Factors: “Brown fat cell” https://www.scientificanimations.com/ / CC BY-SA 4.0 (cropped)
- Regulation of Adipocytes by Nutrient Signals: “Inzulínová pera” Mr Hyde at Czech Wikipedia (Original text: moje foto) / Public domain (cropped)
- Development of Novel Biomarkers: “Internal carotid artery stenosis in ultrasound near occlusion” Mme Mim / CC BY-SA 3.0 (cropped)
- Related lab (Acute and Palliative Care Lab): “Patient lying in hospital bed in intensive care unit in Germany in 2015” Pittigrilli / CC BY-SA 4.0 (cropped)
- Related lab (Perioperative Management Lab): “AusMAT team members performing surgery ( )” Department of Foreign Affairs and Trade / CC BY 2.0 (cropped)
- Related lab (Psychiatric and Mental Health Nursing Lab): “Nursing staff, St Mary's Hospital” Ardosion / CC BY-SA 4.0 (cropped)
- Related lab (Chronic Illness Nursing Lab): “Nurse checks blood pressure” Linda Bartlett (Photographer) / Public domain (cropped)
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